An ISFET-based anion sensor for the potentiometric detection of organic acids in liquid chromatography

I. Poels, Richardus B.M. Schasfoort, S. Picioreanu, J. Frank, G.W.K. van Dedem, Albert van den Berg, L.J. Nagels

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An ion-selective field effect transistor (ISFET) was applied as a potentiometric detector in liquid chromatography (LC) for the determination of organic acids. The ISFET was prepared by coating the gate insulator of the encapsulated transistor with a poly(vinyl chloride) (PVC) matrix membrane containing methyltridodecylammoniumchloride, which enables the detection of organic anions. The ISFET was tested for its applicability as detector for carboxylic acids in ion-exchange and reversed-phase chromatography. Its analytical characteristics were compared to those of a coated-wire electrode (CWE) and of a conventional type of ion-selective electrode (ISE).
Original languageUndefined
Pages (from-to)194-299
Number of pages6
JournalSensors and actuators. B: Chemical
Issue number67 is3
Publication statusPublished - 2000


  • METIS-111716
  • IR-14644

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