### Abstract

Original language | Undefined |
---|---|

Pages (from-to) | 529-549 |

Number of pages | 21 |

Journal | Computers in biology and medicine |

Volume | 31 |

Issue number | 6 |

DOIs | |

Publication status | Published - Nov 2002 |

### Keywords

- EWI-13997
- METIS-209229
- IR-74610
- Ceftazidime
- Ciprofloxacin
- Aminoglycosides
- Antibiotics
- Lethality
- Pharmacodynamics
- Pharmacokinetics

### Cite this

*Computers in biology and medicine*,

*31*(6), 529-549. https://doi.org/10.1016/S0010-4825(02)00035-5

}

*Computers in biology and medicine*, vol. 31, no. 6, pp. 529-549. https://doi.org/10.1016/S0010-4825(02)00035-5

**Analogy between temperature-dependent and concentration-dependent bacterial killing.** / Neef, C.; van Gils, Stephanus A.; Ijzerman, W.L.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Analogy between temperature-dependent and concentration-dependent bacterial killing

AU - Neef, C.

AU - van Gils, Stephanus A.

AU - Ijzerman, W.L.

PY - 2002/11

Y1 - 2002/11

N2 - In this article an analogy between temperature-dependent and concentration-dependent bacterial killing is described. The validation process of autoclaves uses parameters such as reduction rate constant k, decimal reduction time D and resistance coefficient z from an imaginary microorganism to describe the sterilization process. Total lethality of the process is calculated as the integral of the lethality (a function of the temperature) over time. In the case of concentration-dependent killing - i.e. using antibiotic drugs - the k-value is not necessarily a constant; it is the difference between growth and killing of the microorganism. Equations are derived for the decimal reduction time D and resistance coefficient z. Pharmacodynamic models of tobramycin, ciprofloxacin and ceftazidime are used to demonstrate that there is an optimal concentration for all three drugs: Copt-tobra=3.20MIC mg/l, Copt-cipro=3.45MIC mg/l and Copt-cefta=1.35MIC mg/l.

AB - In this article an analogy between temperature-dependent and concentration-dependent bacterial killing is described. The validation process of autoclaves uses parameters such as reduction rate constant k, decimal reduction time D and resistance coefficient z from an imaginary microorganism to describe the sterilization process. Total lethality of the process is calculated as the integral of the lethality (a function of the temperature) over time. In the case of concentration-dependent killing - i.e. using antibiotic drugs - the k-value is not necessarily a constant; it is the difference between growth and killing of the microorganism. Equations are derived for the decimal reduction time D and resistance coefficient z. Pharmacodynamic models of tobramycin, ciprofloxacin and ceftazidime are used to demonstrate that there is an optimal concentration for all three drugs: Copt-tobra=3.20MIC mg/l, Copt-cipro=3.45MIC mg/l and Copt-cefta=1.35MIC mg/l.

KW - EWI-13997

KW - METIS-209229

KW - IR-74610

KW - Ceftazidime

KW - Ciprofloxacin

KW - Aminoglycosides

KW - Antibiotics

KW - Lethality

KW - Pharmacodynamics

KW - Pharmacokinetics

U2 - 10.1016/S0010-4825(02)00035-5

DO - 10.1016/S0010-4825(02)00035-5

M3 - Article

VL - 31

SP - 529

EP - 549

JO - Computers in biology and medicine

JF - Computers in biology and medicine

SN - 0010-4825

IS - 6

ER -