Analysis of Circulating Tumor Cells, Fragments, and Debris

Galla Chandra Rao (Inventor), Christopher Larson (Inventor), Madeline Repollet (Inventor), Herman Rutner (Inventor), Leon W.M.M. Terstappen (Inventor), Shawn Mark O' Hara (Inventor), Steven Gross (Inventor)

Research output: Patent

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Abstract

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotterĀ® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.
Original languageEnglish
Patent number7,863,012 B2
Priority date4/01/11
Filing date17/02/04
Publication statusPublished - 4 Jan 2011

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    Rao, G. C., Larson, C., Repollet, M., Rutner, H., Terstappen, L. W. M. M., O' Hara, S. M., & Gross, S. (2011). Analysis of Circulating Tumor Cells, Fragments, and Debris. (Patent No. 7,863,012 B2).