Analysis of heart rate variability in children during high flow nasal cannula therapy

M. Perez-Zabalza*, R. Hagmeijer, B. J. Thio, J. Bors, X. Hoppenbrouwer, A. Garde

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    Objective: Heart rate variability (HRV) is a non-invasive measure of the interaction between the autonomic nervous system (ANS) and the cardiovascular system and an indicator of physiologic stress. HRV is proposed as an alternative biomarker to the effect of high flow nasal cannula (HFNC) therapy, a non-invasive ventilation mode, in children with severe respiratory disease. Approach: Seven children with severe acute respiratory disease were included in this pilot study. All of them received HFNC treatment. Standard physiological variables, such as heart rate (HR), breathing rate (BR) and blood oxygen saturation (SpO2) were analyzed during HFNC therapy. HRV, which includes the time domain parameters defined by the mean of RR intervals (avRR), the standard deviation of RR intervals (stdRR), the root mean square of differences between adjacent RR intervals (rmsSD), and the frequency domain parameters defined by spectral powers of low frequency (LF, 0.04 Hz-0.15 Hz) and high frequency (HF, 0.15 Hz-0.4 Hz) bands was also analysed during therapy. Main results: Only the time domain parameter rmsSD showed a significant increase (from 0.03 to 0.08 s, p < 0.05) between the middle and the end of the therapy. No significant changes were observed in HR, BR and SpO2 throughout the therapy. Of these three variables, only HR and BR showed a high and statistically significant positive correlation. Significance: HRV analysis seems to be a promising alternative biomarker to monitor the effect of HFNC therapy on children with severe respiratory disease.

    Original languageEnglish
    Article number045028
    JournalBiomedical Physics and Engineering Express
    Volume5
    Issue number4
    DOIs
    Publication statusPublished - 11 Jul 2019

    Fingerprint

    Heart Rate
    Respiration
    Therapeutics
    Biomarkers
    Noninvasive Ventilation
    Autonomic Nervous System
    Acute Disease
    Cardiovascular System
    Cannula
    Oxygen

    Keywords

    • children
    • heart rate variability
    • high-flow therapy
    • severe respiratory disease

    Cite this

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    title = "Analysis of heart rate variability in children during high flow nasal cannula therapy",
    abstract = "Objective: Heart rate variability (HRV) is a non-invasive measure of the interaction between the autonomic nervous system (ANS) and the cardiovascular system and an indicator of physiologic stress. HRV is proposed as an alternative biomarker to the effect of high flow nasal cannula (HFNC) therapy, a non-invasive ventilation mode, in children with severe respiratory disease. Approach: Seven children with severe acute respiratory disease were included in this pilot study. All of them received HFNC treatment. Standard physiological variables, such as heart rate (HR), breathing rate (BR) and blood oxygen saturation (SpO2) were analyzed during HFNC therapy. HRV, which includes the time domain parameters defined by the mean of RR intervals (avRR), the standard deviation of RR intervals (stdRR), the root mean square of differences between adjacent RR intervals (rmsSD), and the frequency domain parameters defined by spectral powers of low frequency (LF, 0.04 Hz-0.15 Hz) and high frequency (HF, 0.15 Hz-0.4 Hz) bands was also analysed during therapy. Main results: Only the time domain parameter rmsSD showed a significant increase (from 0.03 to 0.08 s, p < 0.05) between the middle and the end of the therapy. No significant changes were observed in HR, BR and SpO2 throughout the therapy. Of these three variables, only HR and BR showed a high and statistically significant positive correlation. Significance: HRV analysis seems to be a promising alternative biomarker to monitor the effect of HFNC therapy on children with severe respiratory disease.",
    keywords = "children, heart rate variability, high-flow therapy, severe respiratory disease",
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    Analysis of heart rate variability in children during high flow nasal cannula therapy. / Perez-Zabalza, M.; Hagmeijer, R.; Thio, B. J.; Bors, J.; Hoppenbrouwer, X.; Garde, A.

    In: Biomedical Physics and Engineering Express, Vol. 5, No. 4, 045028, 11.07.2019.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Analysis of heart rate variability in children during high flow nasal cannula therapy

    AU - Perez-Zabalza, M.

    AU - Hagmeijer, R.

    AU - Thio, B. J.

    AU - Bors, J.

    AU - Hoppenbrouwer, X.

    AU - Garde, A.

    PY - 2019/7/11

    Y1 - 2019/7/11

    N2 - Objective: Heart rate variability (HRV) is a non-invasive measure of the interaction between the autonomic nervous system (ANS) and the cardiovascular system and an indicator of physiologic stress. HRV is proposed as an alternative biomarker to the effect of high flow nasal cannula (HFNC) therapy, a non-invasive ventilation mode, in children with severe respiratory disease. Approach: Seven children with severe acute respiratory disease were included in this pilot study. All of them received HFNC treatment. Standard physiological variables, such as heart rate (HR), breathing rate (BR) and blood oxygen saturation (SpO2) were analyzed during HFNC therapy. HRV, which includes the time domain parameters defined by the mean of RR intervals (avRR), the standard deviation of RR intervals (stdRR), the root mean square of differences between adjacent RR intervals (rmsSD), and the frequency domain parameters defined by spectral powers of low frequency (LF, 0.04 Hz-0.15 Hz) and high frequency (HF, 0.15 Hz-0.4 Hz) bands was also analysed during therapy. Main results: Only the time domain parameter rmsSD showed a significant increase (from 0.03 to 0.08 s, p < 0.05) between the middle and the end of the therapy. No significant changes were observed in HR, BR and SpO2 throughout the therapy. Of these three variables, only HR and BR showed a high and statistically significant positive correlation. Significance: HRV analysis seems to be a promising alternative biomarker to monitor the effect of HFNC therapy on children with severe respiratory disease.

    AB - Objective: Heart rate variability (HRV) is a non-invasive measure of the interaction between the autonomic nervous system (ANS) and the cardiovascular system and an indicator of physiologic stress. HRV is proposed as an alternative biomarker to the effect of high flow nasal cannula (HFNC) therapy, a non-invasive ventilation mode, in children with severe respiratory disease. Approach: Seven children with severe acute respiratory disease were included in this pilot study. All of them received HFNC treatment. Standard physiological variables, such as heart rate (HR), breathing rate (BR) and blood oxygen saturation (SpO2) were analyzed during HFNC therapy. HRV, which includes the time domain parameters defined by the mean of RR intervals (avRR), the standard deviation of RR intervals (stdRR), the root mean square of differences between adjacent RR intervals (rmsSD), and the frequency domain parameters defined by spectral powers of low frequency (LF, 0.04 Hz-0.15 Hz) and high frequency (HF, 0.15 Hz-0.4 Hz) bands was also analysed during therapy. Main results: Only the time domain parameter rmsSD showed a significant increase (from 0.03 to 0.08 s, p < 0.05) between the middle and the end of the therapy. No significant changes were observed in HR, BR and SpO2 throughout the therapy. Of these three variables, only HR and BR showed a high and statistically significant positive correlation. Significance: HRV analysis seems to be a promising alternative biomarker to monitor the effect of HFNC therapy on children with severe respiratory disease.

    KW - children

    KW - heart rate variability

    KW - high-flow therapy

    KW - severe respiratory disease

    U2 - 10.1088/2057-1976/ab2d11

    DO - 10.1088/2057-1976/ab2d11

    M3 - Article

    AN - SCOPUS:85070559348

    VL - 5

    JO - Biomedical Physics and Engineering Express

    JF - Biomedical Physics and Engineering Express

    SN - 2057-1976

    IS - 4

    M1 - 045028

    ER -