Analyzing magnetic nanoparticle content in biological samples: Acsusceptometry using offset fields

M. Visscher, Sebastiaan Waanders, Bernard ten Haken

Research output: Contribution to conferenceAbstractOther research output

Abstract

The clinical application of magnetic nanoparticles is a developing field with promising perspectives in treatment and diagnosis [1]. After the first applications as a contrast agent in MRI, other magnetic methods have been developed for excitation and detection of magnetic nanoparticles. For magnetic detection, the nonlinear behavior of superparamagnetic iron oxides provide excellent contrast in the linear magnetic human body. To exploit these properties, the design of magnetic nanoparticles as well as detection systems has to be optimized for clinical practice. The particles have to provide optimal sensitivity in contrast to tissue, whereas the signal-to-noise ratio and applicability of a measurement system are important for successful clinical implementation. In this contribution a setup is presented that is able to assess these both elements for sentinel lymph node mapping. Small intact biological samples, such as lymph nodes, can be measured at room temperature to characterize the magnetic nanoparticle content by differential magnetometry. Furthermore, the system can be used as a tool to analyze the magnetic properties of nanoparticles, providing insight in the quality for nonlinear particle detection. © 2013 IEEE.
Original languageEnglish
Pages-
DOIs
Publication statusPublished - 23 Mar 2013
Event3rd International Workshop on Magnetic Particle Imaging, IWMPI 2013 - Berkeley, United States
Duration: 23 Mar 201324 Mar 2013
Conference number: 3

Conference

Conference3rd International Workshop on Magnetic Particle Imaging, IWMPI 2013
Abbreviated titleIWMPI
CountryUnited States
CityBerkeley
Period23/03/1324/03/13

Fingerprint

nanoparticles
lymphatic system
human body
iron oxides
magnetic measurement
signal to noise ratios
magnetic properties
sensitivity
room temperature
excitation

Keywords

  • METIS-301597
  • IR-89393

Cite this

Visscher, M., Waanders, S., & ten Haken, B. (2013). Analyzing magnetic nanoparticle content in biological samples: Acsusceptometry using offset fields. -. Abstract from 3rd International Workshop on Magnetic Particle Imaging, IWMPI 2013, Berkeley, United States. https://doi.org/10.1109/IWMPI.2013.6528357
Visscher, M. ; Waanders, Sebastiaan ; ten Haken, Bernard. / Analyzing magnetic nanoparticle content in biological samples: Acsusceptometry using offset fields. Abstract from 3rd International Workshop on Magnetic Particle Imaging, IWMPI 2013, Berkeley, United States.
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Visscher, M, Waanders, S & ten Haken, B 2013, 'Analyzing magnetic nanoparticle content in biological samples: Acsusceptometry using offset fields' 3rd International Workshop on Magnetic Particle Imaging, IWMPI 2013, Berkeley, United States, 23/03/13 - 24/03/13, pp. -. https://doi.org/10.1109/IWMPI.2013.6528357

Analyzing magnetic nanoparticle content in biological samples: Acsusceptometry using offset fields. / Visscher, M.; Waanders, Sebastiaan; ten Haken, Bernard.

2013. - Abstract from 3rd International Workshop on Magnetic Particle Imaging, IWMPI 2013, Berkeley, United States.

Research output: Contribution to conferenceAbstractOther research output

TY - CONF

T1 - Analyzing magnetic nanoparticle content in biological samples: Acsusceptometry using offset fields

AU - Visscher, M.

AU - Waanders, Sebastiaan

AU - ten Haken, Bernard

N1 - Conference code: 98041

PY - 2013/3/23

Y1 - 2013/3/23

N2 - The clinical application of magnetic nanoparticles is a developing field with promising perspectives in treatment and diagnosis [1]. After the first applications as a contrast agent in MRI, other magnetic methods have been developed for excitation and detection of magnetic nanoparticles. For magnetic detection, the nonlinear behavior of superparamagnetic iron oxides provide excellent contrast in the linear magnetic human body. To exploit these properties, the design of magnetic nanoparticles as well as detection systems has to be optimized for clinical practice. The particles have to provide optimal sensitivity in contrast to tissue, whereas the signal-to-noise ratio and applicability of a measurement system are important for successful clinical implementation. In this contribution a setup is presented that is able to assess these both elements for sentinel lymph node mapping. Small intact biological samples, such as lymph nodes, can be measured at room temperature to characterize the magnetic nanoparticle content by differential magnetometry. Furthermore, the system can be used as a tool to analyze the magnetic properties of nanoparticles, providing insight in the quality for nonlinear particle detection. © 2013 IEEE.

AB - The clinical application of magnetic nanoparticles is a developing field with promising perspectives in treatment and diagnosis [1]. After the first applications as a contrast agent in MRI, other magnetic methods have been developed for excitation and detection of magnetic nanoparticles. For magnetic detection, the nonlinear behavior of superparamagnetic iron oxides provide excellent contrast in the linear magnetic human body. To exploit these properties, the design of magnetic nanoparticles as well as detection systems has to be optimized for clinical practice. The particles have to provide optimal sensitivity in contrast to tissue, whereas the signal-to-noise ratio and applicability of a measurement system are important for successful clinical implementation. In this contribution a setup is presented that is able to assess these both elements for sentinel lymph node mapping. Small intact biological samples, such as lymph nodes, can be measured at room temperature to characterize the magnetic nanoparticle content by differential magnetometry. Furthermore, the system can be used as a tool to analyze the magnetic properties of nanoparticles, providing insight in the quality for nonlinear particle detection. © 2013 IEEE.

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KW - IR-89393

U2 - 10.1109/IWMPI.2013.6528357

DO - 10.1109/IWMPI.2013.6528357

M3 - Abstract

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Visscher M, Waanders S, ten Haken B. Analyzing magnetic nanoparticle content in biological samples: Acsusceptometry using offset fields. 2013. Abstract from 3rd International Workshop on Magnetic Particle Imaging, IWMPI 2013, Berkeley, United States. https://doi.org/10.1109/IWMPI.2013.6528357