Aneurysmal parent artery-specific inflow conditions for complete and incomplete circle of willis configurations

B.M.W. Cornelissen*, J.J. Schneiders, M.E. Sprengers, R. van den Berg, P. van Ooij, A.J. Nederveen, E. van Bavel, W.P. Vandertop, C.H. Slump, H.A. Marquering, C.B.L.M. Majoie

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    3 Citations (Scopus)

    Abstract

    BACKGROUND AND PURPOSE: Hemodynamics are thought to play a role in intracranial aneurysm growth and rupture. Computational fluid dynamics is frequently performed to assess intra-aneurysmal hemodynamics, using generalized flow waveforms of healthy volunteers as inflow boundary conditions. The purpose of this study was to assess differences in inflow conditions for different aneurysmal parent artery locations and variations of circle of Willis configurations.

    MATERIALS AND METHODS: In a series of 96 patients with 103 aneurysms, velocity measurements were acquired using 2D phase-contrast MR imaging perpendicular to the aneurysmal parent arteries in the circle of Willis. Circle of Willis configurations were inspected for variations using multiple overlapping thin-slab-acquisition MRAs. Flow rates, velocity magnitudes, and pulsatility indices were calculated for each parent artery location in subgroups of complete and incomplete circle of Willis configurations. RESULTS: Flow rates, velocity magnitudes, and pulsatility indices were significantly different among aneurysmal parent arteries. Incomplete circle of Willis configurations were observed in 24% of the cases. Significantly lower basilar artery flow rates were observed in configurations with hypoplastic P1 segments. Significantly higher A1 flow rates were observed in configurations with a hypoplastic contralateral A1 segment.

    CONCLUSIONS: Inflow conditions vary substantially between aneurysmal parent arteries and circle of Willis configurations. We have created a collection of parent artery-specific inflow conditions tailored to the patient-specific circle of Willis configuration that can be used in future computational fluid dynamics studies analyzing intra-aneurysmal hemodynamics.

    Original languageEnglish
    Pages (from-to)910-915
    Number of pages6
    JournalAmerican journal of neuroradiology
    Volume39
    Issue number5
    DOIs
    Publication statusPublished - 1 May 2018

    Fingerprint

    Circle of Willis
    Arteries
    Hemodynamics
    Hydrodynamics
    Basilar Artery
    Intracranial Aneurysm
    Aneurysm
    Rupture
    Healthy Volunteers
    Growth

    Cite this

    Cornelissen, B. M. W., Schneiders, J. J., Sprengers, M. E., van den Berg, R., van Ooij, P., Nederveen, A. J., ... Majoie, C. B. L. M. (2018). Aneurysmal parent artery-specific inflow conditions for complete and incomplete circle of willis configurations. American journal of neuroradiology, 39(5), 910-915. https://doi.org/10.3174/ajnr.A5602
    Cornelissen, B.M.W. ; Schneiders, J.J. ; Sprengers, M.E. ; van den Berg, R. ; van Ooij, P. ; Nederveen, A.J. ; van Bavel, E. ; Vandertop, W.P. ; Slump, C.H. ; Marquering, H.A. ; Majoie, C.B.L.M. / Aneurysmal parent artery-specific inflow conditions for complete and incomplete circle of willis configurations. In: American journal of neuroradiology. 2018 ; Vol. 39, No. 5. pp. 910-915.
    @article{940a1dc962bf411d91868afb15272a18,
    title = "Aneurysmal parent artery-specific inflow conditions for complete and incomplete circle of willis configurations",
    abstract = "BACKGROUND AND PURPOSE: Hemodynamics are thought to play a role in intracranial aneurysm growth and rupture. Computational fluid dynamics is frequently performed to assess intra-aneurysmal hemodynamics, using generalized flow waveforms of healthy volunteers as inflow boundary conditions. The purpose of this study was to assess differences in inflow conditions for different aneurysmal parent artery locations and variations of circle of Willis configurations.MATERIALS AND METHODS: In a series of 96 patients with 103 aneurysms, velocity measurements were acquired using 2D phase-contrast MR imaging perpendicular to the aneurysmal parent arteries in the circle of Willis. Circle of Willis configurations were inspected for variations using multiple overlapping thin-slab-acquisition MRAs. Flow rates, velocity magnitudes, and pulsatility indices were calculated for each parent artery location in subgroups of complete and incomplete circle of Willis configurations. RESULTS: Flow rates, velocity magnitudes, and pulsatility indices were significantly different among aneurysmal parent arteries. Incomplete circle of Willis configurations were observed in 24{\%} of the cases. Significantly lower basilar artery flow rates were observed in configurations with hypoplastic P1 segments. Significantly higher A1 flow rates were observed in configurations with a hypoplastic contralateral A1 segment.CONCLUSIONS: Inflow conditions vary substantially between aneurysmal parent arteries and circle of Willis configurations. We have created a collection of parent artery-specific inflow conditions tailored to the patient-specific circle of Willis configuration that can be used in future computational fluid dynamics studies analyzing intra-aneurysmal hemodynamics.",
    author = "B.M.W. Cornelissen and J.J. Schneiders and M.E. Sprengers and {van den Berg}, R. and {van Ooij}, P. and A.J. Nederveen and {van Bavel}, E. and W.P. Vandertop and C.H. Slump and H.A. Marquering and C.B.L.M. Majoie",
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    Cornelissen, BMW, Schneiders, JJ, Sprengers, ME, van den Berg, R, van Ooij, P, Nederveen, AJ, van Bavel, E, Vandertop, WP, Slump, CH, Marquering, HA & Majoie, CBLM 2018, 'Aneurysmal parent artery-specific inflow conditions for complete and incomplete circle of willis configurations', American journal of neuroradiology, vol. 39, no. 5, pp. 910-915. https://doi.org/10.3174/ajnr.A5602

    Aneurysmal parent artery-specific inflow conditions for complete and incomplete circle of willis configurations. / Cornelissen, B.M.W.; Schneiders, J.J.; Sprengers, M.E.; van den Berg, R.; van Ooij, P.; Nederveen, A.J.; van Bavel, E.; Vandertop, W.P.; Slump, C.H.; Marquering, H.A.; Majoie, C.B.L.M.

    In: American journal of neuroradiology, Vol. 39, No. 5, 01.05.2018, p. 910-915.

    Research output: Contribution to journalArticleAcademicpeer-review

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    T1 - Aneurysmal parent artery-specific inflow conditions for complete and incomplete circle of willis configurations

    AU - Cornelissen, B.M.W.

    AU - Schneiders, J.J.

    AU - Sprengers, M.E.

    AU - van den Berg, R.

    AU - van Ooij, P.

    AU - Nederveen, A.J.

    AU - van Bavel, E.

    AU - Vandertop, W.P.

    AU - Slump, C.H.

    AU - Marquering, H.A.

    AU - Majoie, C.B.L.M.

    PY - 2018/5/1

    Y1 - 2018/5/1

    N2 - BACKGROUND AND PURPOSE: Hemodynamics are thought to play a role in intracranial aneurysm growth and rupture. Computational fluid dynamics is frequently performed to assess intra-aneurysmal hemodynamics, using generalized flow waveforms of healthy volunteers as inflow boundary conditions. The purpose of this study was to assess differences in inflow conditions for different aneurysmal parent artery locations and variations of circle of Willis configurations.MATERIALS AND METHODS: In a series of 96 patients with 103 aneurysms, velocity measurements were acquired using 2D phase-contrast MR imaging perpendicular to the aneurysmal parent arteries in the circle of Willis. Circle of Willis configurations were inspected for variations using multiple overlapping thin-slab-acquisition MRAs. Flow rates, velocity magnitudes, and pulsatility indices were calculated for each parent artery location in subgroups of complete and incomplete circle of Willis configurations. RESULTS: Flow rates, velocity magnitudes, and pulsatility indices were significantly different among aneurysmal parent arteries. Incomplete circle of Willis configurations were observed in 24% of the cases. Significantly lower basilar artery flow rates were observed in configurations with hypoplastic P1 segments. Significantly higher A1 flow rates were observed in configurations with a hypoplastic contralateral A1 segment.CONCLUSIONS: Inflow conditions vary substantially between aneurysmal parent arteries and circle of Willis configurations. We have created a collection of parent artery-specific inflow conditions tailored to the patient-specific circle of Willis configuration that can be used in future computational fluid dynamics studies analyzing intra-aneurysmal hemodynamics.

    AB - BACKGROUND AND PURPOSE: Hemodynamics are thought to play a role in intracranial aneurysm growth and rupture. Computational fluid dynamics is frequently performed to assess intra-aneurysmal hemodynamics, using generalized flow waveforms of healthy volunteers as inflow boundary conditions. The purpose of this study was to assess differences in inflow conditions for different aneurysmal parent artery locations and variations of circle of Willis configurations.MATERIALS AND METHODS: In a series of 96 patients with 103 aneurysms, velocity measurements were acquired using 2D phase-contrast MR imaging perpendicular to the aneurysmal parent arteries in the circle of Willis. Circle of Willis configurations were inspected for variations using multiple overlapping thin-slab-acquisition MRAs. Flow rates, velocity magnitudes, and pulsatility indices were calculated for each parent artery location in subgroups of complete and incomplete circle of Willis configurations. RESULTS: Flow rates, velocity magnitudes, and pulsatility indices were significantly different among aneurysmal parent arteries. Incomplete circle of Willis configurations were observed in 24% of the cases. Significantly lower basilar artery flow rates were observed in configurations with hypoplastic P1 segments. Significantly higher A1 flow rates were observed in configurations with a hypoplastic contralateral A1 segment.CONCLUSIONS: Inflow conditions vary substantially between aneurysmal parent arteries and circle of Willis configurations. We have created a collection of parent artery-specific inflow conditions tailored to the patient-specific circle of Willis configuration that can be used in future computational fluid dynamics studies analyzing intra-aneurysmal hemodynamics.

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    Cornelissen BMW, Schneiders JJ, Sprengers ME, van den Berg R, van Ooij P, Nederveen AJ et al. Aneurysmal parent artery-specific inflow conditions for complete and incomplete circle of willis configurations. American journal of neuroradiology. 2018 May 1;39(5):910-915. https://doi.org/10.3174/ajnr.A5602