Angiography and coronary function, a clinical approach

Martin Gerrit Stoel

Research output: ThesisPhD Thesis - Research external, graduation UT

122 Downloads (Pure)

Abstract

Coronary angiography has the potential to determine coronary function in addition to merely showing coronary anatomy. In this thesis, we describe several facets of angiographic evaluation of coronary flow velocity and function. Measurement of the length of the coronary vessels by means of a guide wire or a 3D angiography-based computer model permits calculation of coronary flow velocity, volume flow, and coronary resistance. In addition, the frame count reserve (FCR), an angiographic method that does not require use of an intracoronary guide wire, can be used as an estimate of coronary flow reserve. This can be performed in an automated way by use of a 4D model, based on coronary angiography. In the setting of primary PCI for STEMI, auxiliary therapeutic options may help to optimize coronary flow. As shown in this thesis, the administration of adenosine and the aspiration of distally embolized thrombi are methods that should be considered to improve coronary flow after primary PCI. To assess myocardial reperfusion in such patients, ST segment resolution on the ECG early after PCI may be used.
Original languageEnglish
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • von Birgelen, Clemens , Supervisor
  • Zijlstra, Felix, Supervisor, External person
Award date11 Oct 2013
Place of PublicationEnschede
Publisher
Print ISBNs978-94-6108-499-6
Publication statusPublished - 11 Oct 2013

Fingerprint

Coronary Angiography
Myocardial Reperfusion
Computer Simulation
Adenosine
Anatomy
Coronary Vessels
Angiography
Electrocardiography
Thrombosis
Therapeutics
ST Elevation Myocardial Infarction

Keywords

  • METIS-297965
  • IR-87389

Cite this

Stoel, M. G. (2013). Angiography and coronary function, a clinical approach. Enschede: Universiteit Twente.
Stoel, Martin Gerrit. / Angiography and coronary function, a clinical approach. Enschede : Universiteit Twente, 2013. 151 p.
@phdthesis{b8805fc48b944168b16a5186e8f91779,
title = "Angiography and coronary function, a clinical approach",
abstract = "Coronary angiography has the potential to determine coronary function in addition to merely showing coronary anatomy. In this thesis, we describe several facets of angiographic evaluation of coronary flow velocity and function. Measurement of the length of the coronary vessels by means of a guide wire or a 3D angiography-based computer model permits calculation of coronary flow velocity, volume flow, and coronary resistance. In addition, the frame count reserve (FCR), an angiographic method that does not require use of an intracoronary guide wire, can be used as an estimate of coronary flow reserve. This can be performed in an automated way by use of a 4D model, based on coronary angiography. In the setting of primary PCI for STEMI, auxiliary therapeutic options may help to optimize coronary flow. As shown in this thesis, the administration of adenosine and the aspiration of distally embolized thrombi are methods that should be considered to improve coronary flow after primary PCI. To assess myocardial reperfusion in such patients, ST segment resolution on the ECG early after PCI may be used.",
keywords = "METIS-297965, IR-87389",
author = "Stoel, {Martin Gerrit}",
year = "2013",
month = "10",
day = "11",
language = "English",
isbn = "978-94-6108-499-6",
publisher = "Universiteit Twente",
school = "University of Twente",

}

Stoel, MG 2013, 'Angiography and coronary function, a clinical approach', University of Twente, Enschede.

Angiography and coronary function, a clinical approach. / Stoel, Martin Gerrit.

Enschede : Universiteit Twente, 2013. 151 p.

Research output: ThesisPhD Thesis - Research external, graduation UT

TY - THES

T1 - Angiography and coronary function, a clinical approach

AU - Stoel, Martin Gerrit

PY - 2013/10/11

Y1 - 2013/10/11

N2 - Coronary angiography has the potential to determine coronary function in addition to merely showing coronary anatomy. In this thesis, we describe several facets of angiographic evaluation of coronary flow velocity and function. Measurement of the length of the coronary vessels by means of a guide wire or a 3D angiography-based computer model permits calculation of coronary flow velocity, volume flow, and coronary resistance. In addition, the frame count reserve (FCR), an angiographic method that does not require use of an intracoronary guide wire, can be used as an estimate of coronary flow reserve. This can be performed in an automated way by use of a 4D model, based on coronary angiography. In the setting of primary PCI for STEMI, auxiliary therapeutic options may help to optimize coronary flow. As shown in this thesis, the administration of adenosine and the aspiration of distally embolized thrombi are methods that should be considered to improve coronary flow after primary PCI. To assess myocardial reperfusion in such patients, ST segment resolution on the ECG early after PCI may be used.

AB - Coronary angiography has the potential to determine coronary function in addition to merely showing coronary anatomy. In this thesis, we describe several facets of angiographic evaluation of coronary flow velocity and function. Measurement of the length of the coronary vessels by means of a guide wire or a 3D angiography-based computer model permits calculation of coronary flow velocity, volume flow, and coronary resistance. In addition, the frame count reserve (FCR), an angiographic method that does not require use of an intracoronary guide wire, can be used as an estimate of coronary flow reserve. This can be performed in an automated way by use of a 4D model, based on coronary angiography. In the setting of primary PCI for STEMI, auxiliary therapeutic options may help to optimize coronary flow. As shown in this thesis, the administration of adenosine and the aspiration of distally embolized thrombi are methods that should be considered to improve coronary flow after primary PCI. To assess myocardial reperfusion in such patients, ST segment resolution on the ECG early after PCI may be used.

KW - METIS-297965

KW - IR-87389

M3 - PhD Thesis - Research external, graduation UT

SN - 978-94-6108-499-6

PB - Universiteit Twente

CY - Enschede

ER -

Stoel MG. Angiography and coronary function, a clinical approach. Enschede: Universiteit Twente, 2013. 151 p.