Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N-sulfate content

L.C. Sederel; L. van der Does; J.F. van Duijl; T. Beugeling; A. Bantjes

doi:10.1002/jbm.820150606

Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N-sulfate content

L.C. Sederel, L. van der Does, J.F. van Duijl, T. Beugeling, A. Bantjes

Biomaterials Science and Technology

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Abstract

Addition of chlorosulfonyl isocyanate to C=C bonds in cis-1,4-polyisoprene and reaction of the adduct with NaOH resulted in the formation of a water-soluble polyelectrolyte with N-sulfate and carboxylate groups. The polyelectrolyte showed anticoagulant activity and it was found, just as with heparin, that the activity was related to molecular weight and N-sulfate content.

Original language	English
Pages (from-to)	819-827
Journal	Journal of biomedical materials research
Volume	15
Issue number	6
DOIs	https://doi.org/10.1002/jbm.820150606
Publication status	Published - 1981

Keywords

IR-70740

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title = "Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N-sulfate content",

abstract = "Addition of chlorosulfonyl isocyanate to C=C bonds in cis-1,4-polyisoprene and reaction of the adduct with NaOH resulted in the formation of a water-soluble polyelectrolyte with N-sulfate and carboxylate groups. The polyelectrolyte showed anticoagulant activity and it was found, just as with heparin, that the activity was related to molecular weight and N-sulfate content.",

keywords = "IR-70740",

author = "L.C. Sederel and {van der Does}, L. and {van Duijl}, J.F. and T. Beugeling and A. Bantjes",

note = "Part of this work has been presented at the IUPAC International Symposium on Macromolecules, Florence, September 7-12, 1980 ",

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T1 - Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N-sulfate content

AU - Sederel, L.C.

AU - van der Does, L.

AU - van Duijl, J.F.

AU - Beugeling, T.

AU - Bantjes, A.

N1 - Part of this work has been presented at the IUPAC International Symposium on Macromolecules, Florence, September 7-12, 1980

PY - 1981

Y1 - 1981

N2 - Addition of chlorosulfonyl isocyanate to C=C bonds in cis-1,4-polyisoprene and reaction of the adduct with NaOH resulted in the formation of a water-soluble polyelectrolyte with N-sulfate and carboxylate groups. The polyelectrolyte showed anticoagulant activity and it was found, just as with heparin, that the activity was related to molecular weight and N-sulfate content.

AB - Addition of chlorosulfonyl isocyanate to C=C bonds in cis-1,4-polyisoprene and reaction of the adduct with NaOH resulted in the formation of a water-soluble polyelectrolyte with N-sulfate and carboxylate groups. The polyelectrolyte showed anticoagulant activity and it was found, just as with heparin, that the activity was related to molecular weight and N-sulfate content.

KW - IR-70740

U2 - 10.1002/jbm.820150606

DO - 10.1002/jbm.820150606

M3 - Article

SN - 0021-9304

VL - 15

SP - 819

EP - 827

JO - Journal of biomedical materials research

JF - Journal of biomedical materials research

IS - 6

ER -

Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N-sulfate content

Abstract

Keywords

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