Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N-sulfate content

L.C. Sederel, L. van der Does, J.F. van Duijl, T. Beugeling, A. Bantjes

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Addition of chlorosulfonyl isocyanate to C=C bonds in cis-1,4-polyisoprene and reaction of the adduct with NaOH resulted in the formation of a water-soluble polyelectrolyte with N-sulfate and carboxylate groups. The polyelectrolyte showed anticoagulant activity and it was found, just as with heparin, that the activity was related to molecular weight and N-sulfate content.
Original languageEnglish
Pages (from-to)819-827
JournalJournal of biomedical materials research
Issue number6
Publication statusPublished - 1981


  • IR-70740

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