Antithrombin activity of a polyelectrolyte synthesized from cis-1,4-polyisoprene

T. Beugeling; L. van der Does; A. Bantjes; W.L. Sederel

doi:10.1002/jbm.820080605

Antithrombin activity of a polyelectrolyte synthesized from cis-1,4-polyisoprene

T. Beugeling, L. van der Does, A. Bantjes, W.L. Sederel

Biomaterials Science and Technology

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Abstract

A polyelectrolyte synthesized from cis-1,4-polyisoprene, containing aminosulfonate and carboxylate groups was shown to have an anticoagulant activity of about 1/30 compared with heparin. Because the substance prevents the coagulation of plasma in the presence of thrombin it is assumed that it acts as an antithrombin.

Original language	English
Pages (from-to)	375-379
Journal	Journal of biomedical materials research
Volume	8
Issue number	6
DOIs	https://doi.org/10.1002/jbm.820080605
Publication status	Published - 1974

Keywords

IR-70742

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title = "Antithrombin activity of a polyelectrolyte synthesized from cis-1,4-polyisoprene",

abstract = "A polyelectrolyte synthesized from cis-1,4-polyisoprene, containing aminosulfonate and carboxylate groups was shown to have an anticoagulant activity of about 1/30 compared with heparin. Because the substance prevents the coagulation of plasma in the presence of thrombin it is assumed that it acts as an antithrombin.",

keywords = "IR-70742",

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AU - van der Does, L.

AU - Bantjes, A.

AU - Sederel, W.L.

PY - 1974

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AB - A polyelectrolyte synthesized from cis-1,4-polyisoprene, containing aminosulfonate and carboxylate groups was shown to have an anticoagulant activity of about 1/30 compared with heparin. Because the substance prevents the coagulation of plasma in the presence of thrombin it is assumed that it acts as an antithrombin.

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DO - 10.1002/jbm.820080605

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