Apoptosis chip for drug screening

Floor Wolbers

doi:10.3990/1.9789036524995

Apoptosis chip for drug screening

Floor Wolbers

Research output: Thesis › PhD Thesis - Research UT, graduation UT

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Abstract

This thesis describes the process of the development towards a microfluidic platform to perform apoptosis studies on chip in real-time at a single-cell level. The requirements for such cell-based assays are discussed as well as the advantages of using microfluidics for cellular analysis. Our main interest is focused on breast cancer cells. Ultimately, this microfluidic chip has to function as a new analytical device for the clinic to provide patients with the best individual therapy.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Twente
Supervisors/Advisors	van den Berg, Albert, Supervisor Vermes, I., Supervisor Andersson, S.M.H., Supervisor
Thesis sponsors	Dutch Technology Foundation (STW)
Award date	8 Jun 2007
Place of Publication	Zutphen
Publisher	University of Twente
Print ISBNs	978-90-365-2499-5
DOIs	https://doi.org/10.3990/1.9789036524995
Publication status	Published - 8 Jun 2007

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PhD thesis F. WolbersFinal published version, 3 MB

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title = "Apoptosis chip for drug screening",

abstract = "This thesis describes the process of the development towards a microfluidic platform to perform apoptosis studies on chip in real-time at a single-cell level. The requirements for such cell-based assays are discussed as well as the advantages of using microfluidics for cellular analysis. Our main interest is focused on breast cancer cells. Ultimately, this microfluidic chip has to function as a new analytical device for the clinic to provide patients with the best individual therapy.",

author = "Floor Wolbers",

note = "The research described in this thesis was supported by Medisch Spectrum Twente, Hospital Group, Enschede, The Netherlands",

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language = "English",

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N2 - This thesis describes the process of the development towards a microfluidic platform to perform apoptosis studies on chip in real-time at a single-cell level. The requirements for such cell-based assays are discussed as well as the advantages of using microfluidics for cellular analysis. Our main interest is focused on breast cancer cells. Ultimately, this microfluidic chip has to function as a new analytical device for the clinic to provide patients with the best individual therapy.

AB - This thesis describes the process of the development towards a microfluidic platform to perform apoptosis studies on chip in real-time at a single-cell level. The requirements for such cell-based assays are discussed as well as the advantages of using microfluidics for cellular analysis. Our main interest is focused on breast cancer cells. Ultimately, this microfluidic chip has to function as a new analytical device for the clinic to provide patients with the best individual therapy.

U2 - 10.3990/1.9789036524995

DO - 10.3990/1.9789036524995

M3 - PhD Thesis - Research UT, graduation UT

SN - 978-90-365-2499-5

PB - University of Twente

CY - Zutphen

ER -

Apoptosis chip for drug screening

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