Application of Direct Fluid Flow Oscillations to Improve Mixing in Microbioreactors

X. Li, Xueliang Li, G. van der Steen, G.W.K. van Dedem, L.A.A. van der Wielen, W.M. van Gulik, J.J. Heijnen, M. Ottens, E.E. Krommenhoek, Johannes G.E. Gardeniers, Albert van den Berg

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8 Citations (Scopus)


This article describes an active mixing method for a microbioreactor that was designed, simulated, tested, and successfully implemented. By applying a varying pressure to a microchannel looping tangentially into a cylindrical microreactor an oscillating fluid flow was shown to occur. Such an oscillating fluid flow improved mixing, both by diffusion and convection. The oscillating fluid flow has a large impact on the ratio between the diffusion domain and the convection domain. A good match was obtained between experimental mixing results, computational fluid dynamics simulation results and the results of a simplified mixing model thus demonstrating the potential of simulation on improving the design of microreactors. (C) 2009 American Institute of Chemical Engineers AIChE J, 55: 2725-2736, 2009
Original languageUndefined
Article number10.1002/aic.11880
Pages (from-to)2725-2736
Number of pages12
JournalAIChE journal
Issue number10
Publication statusPublished - Oct 2009


  • EWI-16450
  • Taylor dipersion
  • conduits
  • liquid
  • mixer
  • IR-68305
  • Channel
  • Fermentation
  • Micromixers
  • acid
  • METIS-264120
  • solute

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