Application of generalized dispersion theory to vortex chromatography

Eiko Y. Westerbeek, Pierre Gelin, Itzchak Frankel, Wouter Olthuis, Jan C.T. Eijkel, Wim De Malsche*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
71 Downloads (Pure)


Acoustically induced secondary flows are applied to enhance lateral mass transfer beyond the relatively slow diffusion. This has the goal to reduce convective axial dispersion and the resulting band broadening which, in turn, limits the performance of column chromatography. Traditional approaches based on Taylor-Aris model are limited to one-dimensional rectilinear (unidirectional) tube- or channel-flows. We therefore apply the generalized dispersion theory (GDT) allowing for prediction of the dependence of potentially improved performance on the characteristics of the induced secondary flow, channel geometry and solute properties as well as providing qualitative physical insight into the role of lateral flows. Results corroborate agreement with our experimental observations (residual standard deviation, Sres = 3.88) and demonstrate the advantage of applying GDT relative to 3D time-dependent simulations.

Original languageEnglish
Article number462970
JournalJournal of chromatography A
Early online date12 Mar 2022
Publication statusPublished - 10 May 2022


  • Acoustofluidics
  • Generalized Dispersion Theory (GDT)
  • Liquid chromatography
  • Vortex
  • 22/2 OA procedure


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