Are quantitative attenuation measurements of blood by optical coherence tomography feasible?

Dirk J. Faber, Ton van Leeuwen

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

Abstract

We present optical coherence tomography (OCT) measurements on fully physiologically oxygenated blood samples of varying hematocrit. We show that attenuation coefficients cannot be extracted quantitatively using the currently accepted models for the OCT signal from scattering media, because the confidence intervals obtained in the fitting procedure cannot be used as reliable uncertainty estimates of the attenuation coefficients. Better modeling of the hematocrit-dependent OCT signal is needed.
Original languageUndefined
Pages (from-to)1435-1437
Number of pages3
JournalOptics letters
Volume34
Issue number9
DOIs
Publication statusPublished - 2009

Keywords

  • METIS-259804
  • IR-71741

Cite this

Faber, Dirk J. ; van Leeuwen, Ton. / Are quantitative attenuation measurements of blood by optical coherence tomography feasible?. In: Optics letters. 2009 ; Vol. 34, No. 9. pp. 1435-1437.
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Are quantitative attenuation measurements of blood by optical coherence tomography feasible? / Faber, Dirk J.; van Leeuwen, Ton.

In: Optics letters, Vol. 34, No. 9, 2009, p. 1435-1437.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - van Leeuwen, Ton

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AB - We present optical coherence tomography (OCT) measurements on fully physiologically oxygenated blood samples of varying hematocrit. We show that attenuation coefficients cannot be extracted quantitatively using the currently accepted models for the OCT signal from scattering media, because the confidence intervals obtained in the fitting procedure cannot be used as reliable uncertainty estimates of the attenuation coefficients. Better modeling of the hematocrit-dependent OCT signal is needed.

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KW - IR-71741

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