Assessment of bone ingrowth potential of biomimetic hydroxyapatite and brushite coated porous E-beam structures

J. Elizabeth Biemond, Tatiane S. Eufrásio, Gerjon Hannink, Nico Verdonschot, Pieter Buma

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    Abstract

    The bone ingrowth potential of biomimetic hydroxyapatite and brushite coatings applied on porous E-beam structure was examined in goats and compared to a similar uncoated porous structure and a conventional titanium plasma spray coating. Specimens were implanted in the iliac crest of goats for a period of 3 (4 goats) or 15 weeks (8 goats). Mechanical implant fixation generated by bone ingrowth was analyzed by a push out test. Histomorphometry was performed to assess the bone ingrowth depth and bone implant contact. The uncoated and hydroxyapatite-coated cubic structure had significantly higher mechanical strength at the interface compared to the Ti plasma spray coating at 15 weeks of implantation. Bone ingrowth depth was significantly larger for the hydroxyapatite- and brushite-coated structures compared to the uncoated structure. In conclusion, the porous E-beam surface structure showed higher bone ingrowth potential compared to a conventional implant surface after 15 weeks of implantation. Addition of a calcium phosphate coating to the E-beam structure enhanced bone ingrowth significantly. Furthermore, the calcium phosphate coating appears to work as an accelerator for bone ingrowth.
    Original languageEnglish
    Pages (from-to)917-925
    Number of pages9
    JournalJournal of materials science. Materials in medicine
    Volume22
    Issue number4
    DOIs
    Publication statusPublished - 2011

    Keywords

    • METIS-283554
    • Hydroxyapatite
    • Iliac crest
    • Bone ingrowth
    • Calcium phosphate coating
    • Surrounding bone

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