TY - JOUR
T1 - Assessment of differential magnetic susceptibility in nanoparticles
T2 - Effects of changes in viscosity and immobilisation
AU - Riahi, Kalthoum
AU - van de Loosdrecht, Melissa M.
AU - Alic, Lejla
AU - ten Haken, Bennie
PY - 2020/11/15
Y1 - 2020/11/15
N2 - The nonlinear magnetic behaviour of superparamagnetic iron-oxide nanoparticles (SPIONs) has attracted interest as a valuable feature for upcoming medical applications. Injecting SPIONs into the human body affects their magnetic properties through the formation of protein corona or cell immobilisation. It is therefore important to study the effects of environmental changes on the magnetic susceptibility of SPIONs. A superparamagnetic quantifier (SPaQ) is used here to assess the differential magnetic susceptibility of three commercially available SPIONs: Synomag®, Resovist® and Sienna+®. The following experiments were carried out to mimic the influence of the biological environment on the magnetic responses of SPIONs: (i) varying the viscosity of the medium; and (ii) immobilising the nanoparticles by freeze-drying. Differential magnetisation curves as a function of the applied magnetic field were visualised to reveal the dynamic magnetic behaviour of SPIONs in both experiments. Synomag® displayed the lowest decrease (~5%) in differential magnetic susceptibility compared to Resovist® (~33%) and Sienna+® (~21%), for a change from water to a high-viscosity fluid. Although Synomag® showed a clear drop in differential magnetic susceptibility (~58%) after freeze-drying, it still appears to be a promising candidate for clinical applications due to its low sensitivity to changes in viscosity.
AB - The nonlinear magnetic behaviour of superparamagnetic iron-oxide nanoparticles (SPIONs) has attracted interest as a valuable feature for upcoming medical applications. Injecting SPIONs into the human body affects their magnetic properties through the formation of protein corona or cell immobilisation. It is therefore important to study the effects of environmental changes on the magnetic susceptibility of SPIONs. A superparamagnetic quantifier (SPaQ) is used here to assess the differential magnetic susceptibility of three commercially available SPIONs: Synomag®, Resovist® and Sienna+®. The following experiments were carried out to mimic the influence of the biological environment on the magnetic responses of SPIONs: (i) varying the viscosity of the medium; and (ii) immobilising the nanoparticles by freeze-drying. Differential magnetisation curves as a function of the applied magnetic field were visualised to reveal the dynamic magnetic behaviour of SPIONs in both experiments. Synomag® displayed the lowest decrease (~5%) in differential magnetic susceptibility compared to Resovist® (~33%) and Sienna+® (~21%), for a change from water to a high-viscosity fluid. Although Synomag® showed a clear drop in differential magnetic susceptibility (~58%) after freeze-drying, it still appears to be a promising candidate for clinical applications due to its low sensitivity to changes in viscosity.
KW - Brownian relaxation
KW - Differential magnetic susceptibility
KW - Néel relaxation
KW - Superparamagnetic iron-oxide nanoparticles
KW - UT-Hybrid-D
UR - http://www.scopus.com/inward/record.url?scp=85088103596&partnerID=8YFLogxK
U2 - 10.1016/j.jmmm.2020.167238
DO - 10.1016/j.jmmm.2020.167238
M3 - Article
AN - SCOPUS:85088103596
SN - 0304-8853
VL - 514
JO - Journal of magnetism and magnetic materials
JF - Journal of magnetism and magnetic materials
M1 - 167238
ER -