Assessment of Dynamic Change of Coronary Artery Geometry and Its Relationship to Coronary Artery Disease, Based on Coronary CT Angiography

Jordy K. Van Zandwijk*, Volkan Tuncay, Rozemarijn Vliegenthart, Gert Jan Pelgrim, Cornelis H. Slump, Matthijs Oudkerk, Peter M. A. Van Ooijen

*Corresponding author for this work

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Abstract

To investigate the relationship between dynamic changes of coronary artery geometry and coronary artery disease (CAD) using computed tomography (CT). Seventy-one patients underwent coronary CT angiography with retrospective electrocardiographic gating. End-systolic (ES) and end-diastolic (ED) phases were automatically determined by dedicated software. Centerlines were extracted for the right and left coronary artery. Differences between ES and ED curvature and tortuosity were determined. Associations of change in geometrical parameters with plaque types and degree of stenosis were investigated using linear mixed models. The differences in number of inflection points were analyzed using Wilcoxon signed-rank tests. Tests were done on artery and segment level. One hundred thirty-seven arteries (64.3%) and 456 (71.4%) segments were included. Curvature was significantly higher in ES than in ED phase for arteries (p = 0.002) and segments (p < 0.001). The difference was significant only at segment level for tortuosity (p = 0.005). Number of inflection points was significantly higher in ES phase on both artery and segment level (p < 0.001). No significant relationships were found between degree of stenosis and plaque types and dynamic change in geometrical parameters. Non-invasive imaging by cardiac CT can quantify change in geometrical parameters of the coronary arteries during the cardiac cycle. Dynamic change of vessel geometry through the cardiac cycle was not found to be related to the presence of CAD.
Original languageEnglish
Number of pages10
JournalJournal of Digital Imaging
DOIs
Publication statusE-pub ahead of print/First online - 19 Nov 2019

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Angiography
Tomography
Coronary Artery Disease
Coronary Vessels
Arteries
Geometry
Pathologic Constriction
Nonparametric Statistics
Imaging techniques
Linear Models
Software
Computed Tomography Angiography

Keywords

  • UT-Hybrid-D
  • Coronary artery geometry
  • Tortuosity
  • CT angiography
  • Coronary artery disease
  • Curvature
  • Coronary arteries

Cite this

@article{9030e16028f0492bba0b68f4bc7aa9ff,
title = "Assessment of Dynamic Change of Coronary Artery Geometry and Its Relationship to Coronary Artery Disease, Based on Coronary CT Angiography",
abstract = "To investigate the relationship between dynamic changes of coronary artery geometry and coronary artery disease (CAD) using computed tomography (CT). Seventy-one patients underwent coronary CT angiography with retrospective electrocardiographic gating. End-systolic (ES) and end-diastolic (ED) phases were automatically determined by dedicated software. Centerlines were extracted for the right and left coronary artery. Differences between ES and ED curvature and tortuosity were determined. Associations of change in geometrical parameters with plaque types and degree of stenosis were investigated using linear mixed models. The differences in number of inflection points were analyzed using Wilcoxon signed-rank tests. Tests were done on artery and segment level. One hundred thirty-seven arteries (64.3{\%}) and 456 (71.4{\%}) segments were included. Curvature was significantly higher in ES than in ED phase for arteries (p = 0.002) and segments (p < 0.001). The difference was significant only at segment level for tortuosity (p = 0.005). Number of inflection points was significantly higher in ES phase on both artery and segment level (p < 0.001). No significant relationships were found between degree of stenosis and plaque types and dynamic change in geometrical parameters. Non-invasive imaging by cardiac CT can quantify change in geometrical parameters of the coronary arteries during the cardiac cycle. Dynamic change of vessel geometry through the cardiac cycle was not found to be related to the presence of CAD.",
keywords = "UT-Hybrid-D, Coronary artery geometry, Tortuosity, CT angiography, Coronary artery disease, Curvature, Coronary arteries",
author = "{Van Zandwijk}, {Jordy K.} and Volkan Tuncay and Rozemarijn Vliegenthart and Pelgrim, {Gert Jan} and Slump, {Cornelis H.} and Matthijs Oudkerk and {Van Ooijen}, {Peter M. A.}",
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year = "2019",
month = "11",
day = "19",
doi = "10.1007/s10278-019-00300-5",
language = "English",
journal = "Journal of Digital Imaging",
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}

Assessment of Dynamic Change of Coronary Artery Geometry and Its Relationship to Coronary Artery Disease, Based on Coronary CT Angiography. / Van Zandwijk, Jordy K.; Tuncay, Volkan; Vliegenthart, Rozemarijn; Pelgrim, Gert Jan; Slump, Cornelis H.; Oudkerk, Matthijs; Van Ooijen, Peter M. A.

In: Journal of Digital Imaging, 19.11.2019.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Van Zandwijk, Jordy K.

AU - Tuncay, Volkan

AU - Vliegenthart, Rozemarijn

AU - Pelgrim, Gert Jan

AU - Slump, Cornelis H.

AU - Oudkerk, Matthijs

AU - Van Ooijen, Peter M. A.

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N2 - To investigate the relationship between dynamic changes of coronary artery geometry and coronary artery disease (CAD) using computed tomography (CT). Seventy-one patients underwent coronary CT angiography with retrospective electrocardiographic gating. End-systolic (ES) and end-diastolic (ED) phases were automatically determined by dedicated software. Centerlines were extracted for the right and left coronary artery. Differences between ES and ED curvature and tortuosity were determined. Associations of change in geometrical parameters with plaque types and degree of stenosis were investigated using linear mixed models. The differences in number of inflection points were analyzed using Wilcoxon signed-rank tests. Tests were done on artery and segment level. One hundred thirty-seven arteries (64.3%) and 456 (71.4%) segments were included. Curvature was significantly higher in ES than in ED phase for arteries (p = 0.002) and segments (p < 0.001). The difference was significant only at segment level for tortuosity (p = 0.005). Number of inflection points was significantly higher in ES phase on both artery and segment level (p < 0.001). No significant relationships were found between degree of stenosis and plaque types and dynamic change in geometrical parameters. Non-invasive imaging by cardiac CT can quantify change in geometrical parameters of the coronary arteries during the cardiac cycle. Dynamic change of vessel geometry through the cardiac cycle was not found to be related to the presence of CAD.

AB - To investigate the relationship between dynamic changes of coronary artery geometry and coronary artery disease (CAD) using computed tomography (CT). Seventy-one patients underwent coronary CT angiography with retrospective electrocardiographic gating. End-systolic (ES) and end-diastolic (ED) phases were automatically determined by dedicated software. Centerlines were extracted for the right and left coronary artery. Differences between ES and ED curvature and tortuosity were determined. Associations of change in geometrical parameters with plaque types and degree of stenosis were investigated using linear mixed models. The differences in number of inflection points were analyzed using Wilcoxon signed-rank tests. Tests were done on artery and segment level. One hundred thirty-seven arteries (64.3%) and 456 (71.4%) segments were included. Curvature was significantly higher in ES than in ED phase for arteries (p = 0.002) and segments (p < 0.001). The difference was significant only at segment level for tortuosity (p = 0.005). Number of inflection points was significantly higher in ES phase on both artery and segment level (p < 0.001). No significant relationships were found between degree of stenosis and plaque types and dynamic change in geometrical parameters. Non-invasive imaging by cardiac CT can quantify change in geometrical parameters of the coronary arteries during the cardiac cycle. Dynamic change of vessel geometry through the cardiac cycle was not found to be related to the presence of CAD.

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KW - Coronary artery geometry

KW - Tortuosity

KW - CT angiography

KW - Coronary artery disease

KW - Curvature

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