Assessment of respiratory flow cycle morphology in patients with chronic heart failure

Ainara Garde, Leif Sörnmo, Pablo Laguna, Raimon Jané, Salvador Benito, Antoni Bayés‑Genís, Beatriz F. Giraldo

    Research output: Contribution to journalArticleAcademicpeer-review

    4 Citations (Scopus)

    Abstract

    Breathing pattern as periodic breathing (PB) in chronic heart failure (CHF) is associated with poor prognosis and high mortality risk. This work investigates the significance of a number of time domain parameters for characterizing respiratory flow cycle morphology in patients with CHF. Thus, our primary goal is to detect PB pattern and identify patients at higher risk. In addition, differences in respiratory flow cycle morphology between CHF patients (with and without PB) and healthy subjects are studied. Differences between these parameters are assessed by investigating the following three classification issues: CHF patients with PB versus with non-periodic breathing (nPB), CHF patients (both PB and nPB) versus healthy subjects, and nPB patients versus healthy subjects. Twenty-six CHF patients (8/18 with PB/nPB) and 35 healthy subjects are studied. The results show that the maximal expiratory flow interval is shorter and with lower dispersion in CHF patients than in healthy subjects. The flow slopes are much steeper in CHF patients, especially for PB. Both inspiration and expiration durations are reduced in CHF patients, mostly for PB. Using the classification and regression tree technique, the most discriminant parameters are selected. For signals shorter than 1 min, the time domain parameters produce better results than the spectral parameters, with accuracies for each classification of 82/78, 89/85, and 91/89 %, respectively. It is concluded that morphologic analysis in the time domain is useful, especially when short signals are analyzed.
    Original languageEnglish
    Pages (from-to)245–255
    Number of pages11
    JournalMedical & biological engineering & computing
    Volume55
    Issue number2
    DOIs
    Publication statusPublished - 2016

    Keywords

    • Chronic heart failure
    • Ensemble average
    • Periodic and non-periodic breathing
    • Respiratory pattern

    Cite this