TY - JOUR
T1 - Assessment of the relation between initial culprit vessel patency in acute ST-elevation myocardial infarction and endothelial function
AU - Kandhai-Ragunath, Jasveen
AU - Jorstad, Harald T.
AU - de Wagenaar, Bjorn
AU - de Man, Frits H.A.F.
AU - Stoel, Martin G.
AU - van Es, Jan
AU - Doelman, Cees J.A.
AU - Doggen, Carine J.M.
AU - Peters, Ron J.G.
AU - von Birgelen, Clemens
PY - 2014
Y1 - 2014
N2 - Aims: To assess whether better endothelial function increases the likelihood of patients with acute ST-elevation myocardial infarction (STEMI) having initially patent culprit vessels. Clinical data on the relation between endothelial function and culprit vessel patency in STEMI patients are scarce.Methods and results: In this prospective cohort study in 71 patients with STEMI, endothelial function was non-invasively assessed by use of the reactive hyperaemia peripheral artery tonometry (RH-PAT) method at four to six weeks after the primary percutaneous coronary intervention (PPCI). The RH-PAT index measured on average 1.90±0.58. In patients with patent culprit vessels before PPCI (n=33, 46.5%), endothelial function was significantly better than in patients with occluded vessels (n=38, 53.5%) (RH-PAT index 2.08±0.34 vs. 1.75±0.35; p<0.007). Compared to patients with normal endothelial function, the patients with severe endothelial dysfunction had a fivefold higher risk of presenting with an occluded culprit vessel (OR 5.1, 95% CI: 1.8-14.2). Logistic regression analysis revealed that this relation between endothelial function and vessel patency became even stronger after adjustment for potential confounders (adjusted OR 7.1, 95% CI: 2.1-23.6).Conclusions: In this series of patients with acute STEMI, better endothelial function was independently associated with a higher likelihood of presenting with an initially patent culprit vessel. - See more at: http://www.pcronline.com/eurointervention/78th_issue/137/#sthash.qG5DbUl1.dpuf
AB - Aims: To assess whether better endothelial function increases the likelihood of patients with acute ST-elevation myocardial infarction (STEMI) having initially patent culprit vessels. Clinical data on the relation between endothelial function and culprit vessel patency in STEMI patients are scarce.Methods and results: In this prospective cohort study in 71 patients with STEMI, endothelial function was non-invasively assessed by use of the reactive hyperaemia peripheral artery tonometry (RH-PAT) method at four to six weeks after the primary percutaneous coronary intervention (PPCI). The RH-PAT index measured on average 1.90±0.58. In patients with patent culprit vessels before PPCI (n=33, 46.5%), endothelial function was significantly better than in patients with occluded vessels (n=38, 53.5%) (RH-PAT index 2.08±0.34 vs. 1.75±0.35; p<0.007). Compared to patients with normal endothelial function, the patients with severe endothelial dysfunction had a fivefold higher risk of presenting with an occluded culprit vessel (OR 5.1, 95% CI: 1.8-14.2). Logistic regression analysis revealed that this relation between endothelial function and vessel patency became even stronger after adjustment for potential confounders (adjusted OR 7.1, 95% CI: 2.1-23.6).Conclusions: In this series of patients with acute STEMI, better endothelial function was independently associated with a higher likelihood of presenting with an initially patent culprit vessel. - See more at: http://www.pcronline.com/eurointervention/78th_issue/137/#sthash.qG5DbUl1.dpuf
KW - IR-100503
KW - METIS-307072
KW - Myocardial infarction
KW - Coronary artery disease
KW - ST-elevation myocardial infarction (STEMI)
KW - Endothelial function
KW - Culprit vessel patency
KW - Reactive hyperaemia peripheral artery tonometry
U2 - 10.4244/EIJV10I7A137
DO - 10.4244/EIJV10I7A137
M3 - Article
SN - 1774-024X
VL - 10
SP - 784
EP - 791
JO - EuroIntervention
JF - EuroIntervention
IS - 7
M1 - 137
ER -