TY - JOUR
T1 - Assessment of the VAD – Native ventricle pumping system by an equivalent pump
T2 - A computational model based procedure
AU - Ferrari, Gianfranco
AU - Di Molfetta, Arianna
AU - Zieliński, Krzysztof
AU - Cusimano, Valerio
AU - Darowski, Marek
AU - Kozarski, Maciej
AU - Fresiello, Libera
N1 - Publisher Copyright:
© 2021 Nalecz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Objectives: To assess the interaction between a continuous flow pump (CFP) and the native ventricle (NV) when both pumps are giving a flow contribution. Methods and results: The pumping system, composed of NV and of CFP, is replaced by an equivalent pump (EP) with the same NV filling characteristics and heart rate. It is assumed that EP cardiac output is equal to the sum of NV and CFP flows and that its Emax is correlated to the CFP pump speed. Both the pumping system and EP are addressed with a closed loop lumped parameters cardiovascular model connected to a Heart Mate II (HM-II) CFP. The experiments were performed to: 1: verify EP Emax correlation with CFP speed. Resulting correlation:∼0.98; 2: verify EP parameters calculation accuracy, in comparison with the pumping system parameters for different values of peripheral resistance, Emax_NV, HR and CFP speed (8000–11000 RPM). Resulting average error: less than 4%; 3: show how EP can be used to obtain the desired haemodynamic or energetic conditions, then feeding the results into the pumping system, so as to regulate CFP speed accordingly. Conclusions: EP merges the properties of the pumping system composed of NV and CFP into a single pulsatile pump. The described methodology can be a useful support to optimise both haemodynamic and energetic variables in the pumping system when, with the simultaneous presence of CFP and NV flows, flow distribution between the two pumps becomes a critical issue.
AB - Objectives: To assess the interaction between a continuous flow pump (CFP) and the native ventricle (NV) when both pumps are giving a flow contribution. Methods and results: The pumping system, composed of NV and of CFP, is replaced by an equivalent pump (EP) with the same NV filling characteristics and heart rate. It is assumed that EP cardiac output is equal to the sum of NV and CFP flows and that its Emax is correlated to the CFP pump speed. Both the pumping system and EP are addressed with a closed loop lumped parameters cardiovascular model connected to a Heart Mate II (HM-II) CFP. The experiments were performed to: 1: verify EP Emax correlation with CFP speed. Resulting correlation:∼0.98; 2: verify EP parameters calculation accuracy, in comparison with the pumping system parameters for different values of peripheral resistance, Emax_NV, HR and CFP speed (8000–11000 RPM). Resulting average error: less than 4%; 3: show how EP can be used to obtain the desired haemodynamic or energetic conditions, then feeding the results into the pumping system, so as to regulate CFP speed accordingly. Conclusions: EP merges the properties of the pumping system composed of NV and CFP into a single pulsatile pump. The described methodology can be a useful support to optimise both haemodynamic and energetic variables in the pumping system when, with the simultaneous presence of CFP and NV flows, flow distribution between the two pumps becomes a critical issue.
KW - Circulatory model
KW - End-systolic pressure
KW - Equivalent pump
KW - Lumped parameters model
KW - Mechanical circulatory assistance
KW - Ventricular elastance
UR - http://www.scopus.com/inward/record.url?scp=85108214451&partnerID=8YFLogxK
U2 - 10.1016/j.bbe.2021.05.006
DO - 10.1016/j.bbe.2021.05.006
M3 - Article
AN - SCOPUS:85108214451
SN - 0208-5216
VL - 41
SP - 1365
EP - 1377
JO - Biocybernetics and biomedical engineering
JF - Biocybernetics and biomedical engineering
IS - 4
ER -