Association between somatosensory evoked potentials and EEG in comatose patients after cardiac arrest

Astrid B. Glimmerveen, Barry J. Ruijter, Hanneke M. Keijzer, Marleen C. Tjepkema-Cloostermans, Michel J.A.M. van Putten, Jeannette Hofmeijer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To analyze the association between SSEP results and EEG results in comatose patients after cardiac arrest, including the added value of repeated SSEP measurements. Methods: Continuous EEG was measured in 619 patients during the first 3–5 days after cardiac arrest. SSEPs were recorded daily in the first 55 patients, and on indication in later patients. EEGs were visually classified at 12, 24, 48, and 72 h after cardiac arrest, and at the time of SSEP. Outcome at 6 m was dichotomized as good (Cerebral Performance Category 1–2) or poor (CPC 3–5). SSEP and EEG results were related to outcome. Additionally, SSEP results were related to the EEG patterns at the time of SSEP. Results: Absent SSEP responses and suppressed or synchronous EEG on suppressed background ≥24 h after cardiac arrest were invariably associated with poor outcome. SSEP and EEG identified different patients with poor outcome (joint sensitivity 39% at specificity 100%). N20 responses were always preserved in continuous traces at >8 Hz. Absent SSEPs did not re-emerge during the first five days. Conclusions: SSEP and EEG results may diverge after cardiac arrest. Significance: SSEP and EEG together identify more patients without chance of recovery than one of these alone.

Original languageEnglish
Pages (from-to)2026-2031
Number of pages6
JournalClinical neurophysiology
Volume130
Issue number11
Early online date31 Aug 2019
DOIs
Publication statusPublished - 1 Nov 2019

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Somatosensory Evoked Potentials
Coma
Heart Arrest
Electroencephalography
Joints

Keywords

  • Cardiac arrest
  • EEG
  • Postanoxic coma
  • Prognosis
  • SSEP

Cite this

@article{709fa9d2949545f3a57cfe807699363c,
title = "Association between somatosensory evoked potentials and EEG in comatose patients after cardiac arrest",
abstract = "Objective: To analyze the association between SSEP results and EEG results in comatose patients after cardiac arrest, including the added value of repeated SSEP measurements. Methods: Continuous EEG was measured in 619 patients during the first 3–5 days after cardiac arrest. SSEPs were recorded daily in the first 55 patients, and on indication in later patients. EEGs were visually classified at 12, 24, 48, and 72 h after cardiac arrest, and at the time of SSEP. Outcome at 6 m was dichotomized as good (Cerebral Performance Category 1–2) or poor (CPC 3–5). SSEP and EEG results were related to outcome. Additionally, SSEP results were related to the EEG patterns at the time of SSEP. Results: Absent SSEP responses and suppressed or synchronous EEG on suppressed background ≥24 h after cardiac arrest were invariably associated with poor outcome. SSEP and EEG identified different patients with poor outcome (joint sensitivity 39{\%} at specificity 100{\%}). N20 responses were always preserved in continuous traces at >8 Hz. Absent SSEPs did not re-emerge during the first five days. Conclusions: SSEP and EEG results may diverge after cardiac arrest. Significance: SSEP and EEG together identify more patients without chance of recovery than one of these alone.",
keywords = "Cardiac arrest, EEG, Postanoxic coma, Prognosis, SSEP",
author = "Glimmerveen, {Astrid B.} and Ruijter, {Barry J.} and Keijzer, {Hanneke M.} and Tjepkema-Cloostermans, {Marleen C.} and {van Putten}, {Michel J.A.M.} and Jeannette Hofmeijer",
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Association between somatosensory evoked potentials and EEG in comatose patients after cardiac arrest. / Glimmerveen, Astrid B.; Ruijter, Barry J.; Keijzer, Hanneke M.; Tjepkema-Cloostermans, Marleen C.; van Putten, Michel J.A.M.; Hofmeijer, Jeannette.

In: Clinical neurophysiology, Vol. 130, No. 11, 01.11.2019, p. 2026-2031.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Association between somatosensory evoked potentials and EEG in comatose patients after cardiac arrest

AU - Glimmerveen, Astrid B.

AU - Ruijter, Barry J.

AU - Keijzer, Hanneke M.

AU - Tjepkema-Cloostermans, Marleen C.

AU - van Putten, Michel J.A.M.

AU - Hofmeijer, Jeannette

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Objective: To analyze the association between SSEP results and EEG results in comatose patients after cardiac arrest, including the added value of repeated SSEP measurements. Methods: Continuous EEG was measured in 619 patients during the first 3–5 days after cardiac arrest. SSEPs were recorded daily in the first 55 patients, and on indication in later patients. EEGs were visually classified at 12, 24, 48, and 72 h after cardiac arrest, and at the time of SSEP. Outcome at 6 m was dichotomized as good (Cerebral Performance Category 1–2) or poor (CPC 3–5). SSEP and EEG results were related to outcome. Additionally, SSEP results were related to the EEG patterns at the time of SSEP. Results: Absent SSEP responses and suppressed or synchronous EEG on suppressed background ≥24 h after cardiac arrest were invariably associated with poor outcome. SSEP and EEG identified different patients with poor outcome (joint sensitivity 39% at specificity 100%). N20 responses were always preserved in continuous traces at >8 Hz. Absent SSEPs did not re-emerge during the first five days. Conclusions: SSEP and EEG results may diverge after cardiac arrest. Significance: SSEP and EEG together identify more patients without chance of recovery than one of these alone.

AB - Objective: To analyze the association between SSEP results and EEG results in comatose patients after cardiac arrest, including the added value of repeated SSEP measurements. Methods: Continuous EEG was measured in 619 patients during the first 3–5 days after cardiac arrest. SSEPs were recorded daily in the first 55 patients, and on indication in later patients. EEGs were visually classified at 12, 24, 48, and 72 h after cardiac arrest, and at the time of SSEP. Outcome at 6 m was dichotomized as good (Cerebral Performance Category 1–2) or poor (CPC 3–5). SSEP and EEG results were related to outcome. Additionally, SSEP results were related to the EEG patterns at the time of SSEP. Results: Absent SSEP responses and suppressed or synchronous EEG on suppressed background ≥24 h after cardiac arrest were invariably associated with poor outcome. SSEP and EEG identified different patients with poor outcome (joint sensitivity 39% at specificity 100%). N20 responses were always preserved in continuous traces at >8 Hz. Absent SSEPs did not re-emerge during the first five days. Conclusions: SSEP and EEG results may diverge after cardiac arrest. Significance: SSEP and EEG together identify more patients without chance of recovery than one of these alone.

KW - Cardiac arrest

KW - EEG

KW - Postanoxic coma

KW - Prognosis

KW - SSEP

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JO - Clinical neurophysiology

JF - Clinical neurophysiology

SN - 1388-2457

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ER -