Association of the alpha-adducin polymorphism with blood pressure and risk of myocardial infarction

B.M. Psaty*, C. Doggen, H.L. Vos, J.P. Vandenbroucke, F.R. Rosendaal

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)
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Abstract

Genetic variation in adducin, a protein associated with the inner leaflet of the plasma membrane, may be in part responsible for salt-sensitive hypertension. In the Netherlands, 560 men who survived a myocardial infarction and 646 men who had undergone an orthopaedic intervention participated in a case-control study. In men in this study, the -adducin polymorphism was not associated with the risk of myocardial infarction either among those with or among those without a clinical history of hypertension. In a cross-sectional analysis of blood pressure data from the controls, the -adducin polymorphism was associated neither with self-reported hypertension (OR = 0.78, 95% CI = 0.51-1.19) nor with mean levels of systolic or diastolic blood pressure. Additional studies in other populations are needed to assess the contribution of -adducin to high blood pressure and cardiovascular risk.
Original languageEnglish
Pages (from-to)95-97
JournalJournal of human hypertension
Volume14
Issue number2
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • α-Adducin
  • Myocardial infarction
  • Genetics
  • Blood pressure

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