Association of the TGF-Β receptor genes with abdominal aortic aneurysm

A.F. Baas, J. Medic, R. van 't Slot, C.G. de Kovel, A. Zhernakova, R.H. Geelkerken, S.E. Kranendonk, S.M. van Sterkenburg, D.E. Grobbee, A.P. Boll, C. Wijmenga, J.D. Blankensteijn, Y.M. Ruigrok

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)

Abstract

Abdominal aortic aneurysm (AAA) is a multifactorial condition. The transforming growth factor Β (TGF-Β) pathway regulates vascular remodeling and mutations in its receptor genes, TGFBR1 and TGFBR2, cause syndromes with thoracic aortic aneurysm (TAA). The TGF-Β pathway may be involved in aneurysm development in general. We performed an association study by analyzing all the common genetic variants in TGFBR1 and TGFBR2 using tag single nucleotide polymorphisms (SNPs) in a Dutch AAA case-control population in a two-stage genotyping approach. In stage 1, analyzing 376 cases and 648 controls, three of the four TGFBR1 SNPs and nine of the 28 TGFBR2 SNPs had a P0.07. Genotyping of these SNPs in an independent cohort of 360 cases and 376 controls in stage 2 confirmed association (P0.05) for the same allele of one SNP in TGFBR1 and two SNPs in TGFBR2. Joint analysis of the 736 cases and 1024 controls showed statistically significant associations of these SNPs, which sustained after proper correction for multiple testing (TGFBR1 rs1626340 OR 1.32 95% CI 1.11-1.56 P0.001 and TGFBR2 rs1036095 OR 1.32 95% CI 1.12-1.54 P0.001 and rs4522809 OR 1.28 95% CI 1.12-1.46 P0.0004). We conclude that genetic variations in TGFBR1 and TGFBR2 associate with AAA in the Dutch population. This suggests that AAA may develop partly by similar defects as TAA, which in the future may provide novel therapeutic options.

Original languageEnglish
Pages (from-to)240-244
Number of pages5
JournalEuropean journal of human genetics
Volume18
Issue number2
DOIs
Publication statusPublished - 1 Feb 2010
Externally publishedYes

Keywords

  • Abdominal aortic aneurysm
  • Association study
  • TGFBR1
  • TGFBR2
  • Transforming growth factor-b pathway
  • Vascular remodeling

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