Association study of single nucleotide polymorphisms on chromosome 19q13 with abdominal aortic aneurysm

Annette F. Baas, Jelena Medic, Ruben Van'T Slot, Jean Paul P.M. De Vries, Marc R.H.M. Van Sambeek, Bob H. Geelkerken, Bart P. Boll, Diederick E. Grobbee, Cisca Wijmenga, Ynte M. Ruigrok, Jan D. Blankensteijn

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

Background: Abdominal aortic aneurysm (AAA) is a complex disorder in which environmental and genetic factors play a role in pathogenesis. Linkage to 2 adjacent loci on 19q13 in familiar AAA was previously demonstrated. We studied whether genetic variation within these regions predisposes to AAA. Methods: Common genetic variants in the described regions on 19q13 were analyzed using tag single nucleotide polymorphisms (SNPs) in a Dutch case-control population. Single nucleotide polymorphism genotyping was performed in a 2-stage approach. Results: In stage 1, 615 SNPs were genotyped in 376 AAA patients and 648 controls. In stage 2, 8 SNPs of stage 1 with a P value <.015 were genotyped in a second independent cohort of 360 cases and 376 controls. No differences in allele frequencies were observed. Conclusion: Our findings suggest that there are no common AAA predisposing SNPs within the 19q13 loci. Hence, the genetic basis of familiar and sporadic AAA may differ.

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalAngiology
Volume61
Issue number3
DOIs
Publication statusPublished - Jun 2010
Externally publishedYes

Keywords

  • 19q13
  • Abdominal aortic aneurysm
  • Association study
  • Linkage analysis
  • Single nucleotide polymorphism

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