Association study of single nucleotide polymorphisms on chromosome 19q13 with abdominal aortic aneurysm

Annette F. Baas, Jelena Medic, Ruben van 't Slot, Jean-Paul P.M. De Vries, Marc R.H.M. Van Sambeek, Bob H. Geelkerken, Bart P. Boll, Diederick E. Grobbee, Cisca Wijmenga, Ynte M. Ruigrok, Jan D. Blankensteijn

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

Background: Abdominal aortic aneurysm (AAA) is a complex disorder in which environmental and genetic factors play a role in pathogenesis. Linkage to 2 adjacent loci on 19q13 in familiar AAA was previously demonstrated. We studied whether genetic variation within these regions predisposes to AAA. Methods: Common genetic variants in the described regions on 19q13 were analyzed using tag single nucleotide polymorphisms (SNPs) in a Dutch case-control population. Single nucleotide polymorphism genotyping was performed in a 2-stage approach. Results: In stage 1, 615 SNPs were genotyped in 376 AAA patients and 648 controls. In stage 2, 8 SNPs of stage 1 with a P value <.015 were genotyped in a second independent cohort of 360 cases and 376 controls. No differences in allele frequencies were observed. Conclusion: Our findings suggest that there are no common AAA predisposing SNPs within the 19q13 loci. Hence, the genetic basis of familiar and sporadic AAA may differ.

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalAngiology
Volume61
Issue number3
DOIs
Publication statusPublished - Jun 2010
Externally publishedYes

Keywords

  • 19q13
  • Abdominal aortic aneurysm
  • Association study
  • Linkage analysis
  • Single nucleotide polymorphism

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