TY - JOUR
T1 - Association study of single nucleotide polymorphisms on chromosome 19q13 with abdominal aortic aneurysm
AU - Baas, Annette F.
AU - Medic, Jelena
AU - van 't Slot, Ruben
AU - De Vries, Jean-Paul P.M.
AU - Van Sambeek, Marc R.H.M.
AU - Geelkerken, Bob H.
AU - Boll, Bart P.
AU - Grobbee, Diederick E.
AU - Wijmenga, Cisca
AU - Ruigrok, Ynte M.
AU - Blankensteijn, Jan D.
PY - 2010/6
Y1 - 2010/6
N2 - Background: Abdominal aortic aneurysm (AAA) is a complex disorder in which environmental and genetic factors play a role in pathogenesis. Linkage to 2 adjacent loci on 19q13 in familiar AAA was previously demonstrated. We studied whether genetic variation within these regions predisposes to AAA. Methods: Common genetic variants in the described regions on 19q13 were analyzed using tag single nucleotide polymorphisms (SNPs) in a Dutch case-control population. Single nucleotide polymorphism genotyping was performed in a 2-stage approach. Results: In stage 1, 615 SNPs were genotyped in 376 AAA patients and 648 controls. In stage 2, 8 SNPs of stage 1 with a P value <.015 were genotyped in a second independent cohort of 360 cases and 376 controls. No differences in allele frequencies were observed. Conclusion: Our findings suggest that there are no common AAA predisposing SNPs within the 19q13 loci. Hence, the genetic basis of familiar and sporadic AAA may differ.
AB - Background: Abdominal aortic aneurysm (AAA) is a complex disorder in which environmental and genetic factors play a role in pathogenesis. Linkage to 2 adjacent loci on 19q13 in familiar AAA was previously demonstrated. We studied whether genetic variation within these regions predisposes to AAA. Methods: Common genetic variants in the described regions on 19q13 were analyzed using tag single nucleotide polymorphisms (SNPs) in a Dutch case-control population. Single nucleotide polymorphism genotyping was performed in a 2-stage approach. Results: In stage 1, 615 SNPs were genotyped in 376 AAA patients and 648 controls. In stage 2, 8 SNPs of stage 1 with a P value <.015 were genotyped in a second independent cohort of 360 cases and 376 controls. No differences in allele frequencies were observed. Conclusion: Our findings suggest that there are no common AAA predisposing SNPs within the 19q13 loci. Hence, the genetic basis of familiar and sporadic AAA may differ.
KW - 19q13
KW - Abdominal aortic aneurysm
KW - Association study
KW - Linkage analysis
KW - Single nucleotide polymorphism
UR - http://www.scopus.com/inward/record.url?scp=77949897640&partnerID=8YFLogxK
U2 - 10.1177/0003319709354752
DO - 10.1177/0003319709354752
M3 - Article
C2 - 20156811
AN - SCOPUS:77949897640
SN - 0003-3197
VL - 61
SP - 243
EP - 247
JO - Angiology
JF - Angiology
IS - 3
ER -