Associations between collateral status and thrombus characteristics and their impact in anterior circulation stroke

Heitor C. Alves*, Kilian M. Treurniet, Bruna G. Dutra, Ivo G.H. Jansen, Anna M.M. Boers, Emilie M.M. Santos, Olvert A. Berkhemer, Diederik W.J. Dippel, Aad Van Der Lugt, Wim H. Van Zwam, Robert J. Van Oostenbrugge, Hester F. Lingsma, Yvo B.W.E.M. Roos, Albert J. Yoo, Henk A. Marquering, Charles B.L.M. Majoie

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    Abstract

    Background and Purpose-Thrombus characteristics and collateral score are associated with functional outcome in patients with acute ischemic stroke. It has been suggested that they affect each other. The aim of this study is to evaluate the association between clot burden score, thrombus perviousness, and collateral score and to determine whether collateral score influences the association of thrombus characteristics with functional outcome. Methods-Patients with baseline thin-slice noncontrast computed tomography and computed tomographic angiography images from the MR CLEAN trial (Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands) were included (n=195). Collateral score and clot burden scores were determined on baseline computed tomographic angiography. Thrombus attenuation increase was determined by comparing thrombus density on noncontrast computed tomography and computed tomographic angiography using a semiautomated method. The association of collateral score with clot burden score and thrombus attenuation increase was evaluated with linear regression. Mediation and effect modification analyses were used to assess the influence of collateral score on the association of clot burden score and thrombus attenuation increase with functional outcome. Results-A higher clot burden score (B=0.063; 95% confidence interval, 0.008-0.118) and a higher thrombus attenuation increase (B=0.014; 95% confidence interval, 0.003-0.026) were associated with higher collateral score. Collateral score mediated the association of clot burden score with functional outcome. The association between thrombus attenuation increase and functional outcome was modified by the collateral score, and this association was stronger in patients with moderate and good collaterals. Conclusions-Patients with lower thrombus burden and higher thrombus perviousness scores had higher collateral score. The positive effect of thrombus perviousness on clinical outcome was only present in patients with moderate and high collateral scores.

    Original languageEnglish
    Pages (from-to)391-396
    Number of pages6
    JournalStroke
    Volume49
    Issue number2
    DOIs
    Publication statusPublished - 1 Feb 2018

    Keywords

    • Collateral circulation
    • Computed tomography angiography
    • Netherlands
    • Stroke
    • Thrombosis

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