Associations between comorbid load and baseline characteristics in COPD patients with comorbidities: preliminary results

Anke Lenferink, Job van der Palen, Peter Frith, Paul van der Valk, Tanja Effing

Research output: Contribution to journalMeeting AbstractOther research output

Abstract

Chronic Obstructive Pulmonary Disease (COPD) action plans are widely implemented in usual care, but evidence of their use in the presence of comorbidities is limited. Comorbid symptoms may lead to incorrect or delayed treatment actions, and comorbidities often cause hospitalisation and mortality.

In an ongoing controlled trial in the Netherlands and Australia we aim to include 233 COPD patients with ≥ 1 comorbidity. Patients are randomly assigned to an intervention group, with training in the use of a daily symptom diary for their COPD and comorbidities linked to pre-specified individualised actions, or a control group. Follow-up is one year. Associations between the comorbid load and baseline characteristics (e.g. COPD severity, exercise capacity, literacy) will be assessed using multivariate logistic regression analyses.

Baseline characteristics of the first 100 patients (mean age 69.0 ± 9.6; 64.0% male) showed that 43% of the COPD patients had ≥ 2 major comorbidities. Multivariate logistic regression analyses showed that lower cognitive function (Mini Mental State Examination; OR 1.45 (95% CI 1.08-2.00)) and worse emotional function (Chronic Respiratory Questionnaire; OR 1.72 (95% CI 1.02-2.94)) were associated with having ≥ 2 comorbidities. Lower self-reported exercise hours a week (OR 1.09; 95% CI 0.99-1.18) and higher BODE composite score of Body Mass Index, Obstruction, Dyspnoea, and Exercise capacity (OR 1.24; 95% CI 0.91-1.68) were borderline significant.

Diminished cognitive function and worse emotional function are associated with comorbid load in patients with COPD, highlighting the need to account for comorbidities in everyday management of COPD.
Original languageEnglish
Article numberP4751
JournalEuropean respiratory journal. Supplement
Volume44
Issue numberSuppl. 58
Publication statusPublished - 2014

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Chronic Obstructive Pulmonary Disease
Comorbidity
Exercise
Cognition
Logistic Models
Regression Analysis
Netherlands
Dyspnea
Hospitalization
Body Mass Index
Control Groups
Mortality

Cite this

@article{6a8346a00bf74e239de20b57ea1a4b70,
title = "Associations between comorbid load and baseline characteristics in COPD patients with comorbidities: preliminary results",
abstract = "Chronic Obstructive Pulmonary Disease (COPD) action plans are widely implemented in usual care, but evidence of their use in the presence of comorbidities is limited. Comorbid symptoms may lead to incorrect or delayed treatment actions, and comorbidities often cause hospitalisation and mortality.In an ongoing controlled trial in the Netherlands and Australia we aim to include 233 COPD patients with ≥ 1 comorbidity. Patients are randomly assigned to an intervention group, with training in the use of a daily symptom diary for their COPD and comorbidities linked to pre-specified individualised actions, or a control group. Follow-up is one year. Associations between the comorbid load and baseline characteristics (e.g. COPD severity, exercise capacity, literacy) will be assessed using multivariate logistic regression analyses.Baseline characteristics of the first 100 patients (mean age 69.0 ± 9.6; 64.0{\%} male) showed that 43{\%} of the COPD patients had ≥ 2 major comorbidities. Multivariate logistic regression analyses showed that lower cognitive function (Mini Mental State Examination; OR 1.45 (95{\%} CI 1.08-2.00)) and worse emotional function (Chronic Respiratory Questionnaire; OR 1.72 (95{\%} CI 1.02-2.94)) were associated with having ≥ 2 comorbidities. Lower self-reported exercise hours a week (OR 1.09; 95{\%} CI 0.99-1.18) and higher BODE composite score of Body Mass Index, Obstruction, Dyspnoea, and Exercise capacity (OR 1.24; 95{\%} CI 0.91-1.68) were borderline significant.Diminished cognitive function and worse emotional function are associated with comorbid load in patients with COPD, highlighting the need to account for comorbidities in everyday management of COPD.",
author = "Anke Lenferink and {van der Palen}, Job and Peter Frith and {van der Valk}, Paul and Tanja Effing",
year = "2014",
language = "English",
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journal = "European respiratory journal. Supplement",
issn = "0904-1850",
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Associations between comorbid load and baseline characteristics in COPD patients with comorbidities : preliminary results. / Lenferink, Anke ; van der Palen, Job; Frith, Peter; van der Valk, Paul; Effing, Tanja.

In: European respiratory journal. Supplement, Vol. 44, No. Suppl. 58, P4751, 2014.

Research output: Contribution to journalMeeting AbstractOther research output

TY - JOUR

T1 - Associations between comorbid load and baseline characteristics in COPD patients with comorbidities

T2 - preliminary results

AU - Lenferink, Anke

AU - van der Palen, Job

AU - Frith, Peter

AU - van der Valk, Paul

AU - Effing, Tanja

PY - 2014

Y1 - 2014

N2 - Chronic Obstructive Pulmonary Disease (COPD) action plans are widely implemented in usual care, but evidence of their use in the presence of comorbidities is limited. Comorbid symptoms may lead to incorrect or delayed treatment actions, and comorbidities often cause hospitalisation and mortality.In an ongoing controlled trial in the Netherlands and Australia we aim to include 233 COPD patients with ≥ 1 comorbidity. Patients are randomly assigned to an intervention group, with training in the use of a daily symptom diary for their COPD and comorbidities linked to pre-specified individualised actions, or a control group. Follow-up is one year. Associations between the comorbid load and baseline characteristics (e.g. COPD severity, exercise capacity, literacy) will be assessed using multivariate logistic regression analyses.Baseline characteristics of the first 100 patients (mean age 69.0 ± 9.6; 64.0% male) showed that 43% of the COPD patients had ≥ 2 major comorbidities. Multivariate logistic regression analyses showed that lower cognitive function (Mini Mental State Examination; OR 1.45 (95% CI 1.08-2.00)) and worse emotional function (Chronic Respiratory Questionnaire; OR 1.72 (95% CI 1.02-2.94)) were associated with having ≥ 2 comorbidities. Lower self-reported exercise hours a week (OR 1.09; 95% CI 0.99-1.18) and higher BODE composite score of Body Mass Index, Obstruction, Dyspnoea, and Exercise capacity (OR 1.24; 95% CI 0.91-1.68) were borderline significant.Diminished cognitive function and worse emotional function are associated with comorbid load in patients with COPD, highlighting the need to account for comorbidities in everyday management of COPD.

AB - Chronic Obstructive Pulmonary Disease (COPD) action plans are widely implemented in usual care, but evidence of their use in the presence of comorbidities is limited. Comorbid symptoms may lead to incorrect or delayed treatment actions, and comorbidities often cause hospitalisation and mortality.In an ongoing controlled trial in the Netherlands and Australia we aim to include 233 COPD patients with ≥ 1 comorbidity. Patients are randomly assigned to an intervention group, with training in the use of a daily symptom diary for their COPD and comorbidities linked to pre-specified individualised actions, or a control group. Follow-up is one year. Associations between the comorbid load and baseline characteristics (e.g. COPD severity, exercise capacity, literacy) will be assessed using multivariate logistic regression analyses.Baseline characteristics of the first 100 patients (mean age 69.0 ± 9.6; 64.0% male) showed that 43% of the COPD patients had ≥ 2 major comorbidities. Multivariate logistic regression analyses showed that lower cognitive function (Mini Mental State Examination; OR 1.45 (95% CI 1.08-2.00)) and worse emotional function (Chronic Respiratory Questionnaire; OR 1.72 (95% CI 1.02-2.94)) were associated with having ≥ 2 comorbidities. Lower self-reported exercise hours a week (OR 1.09; 95% CI 0.99-1.18) and higher BODE composite score of Body Mass Index, Obstruction, Dyspnoea, and Exercise capacity (OR 1.24; 95% CI 0.91-1.68) were borderline significant.Diminished cognitive function and worse emotional function are associated with comorbid load in patients with COPD, highlighting the need to account for comorbidities in everyday management of COPD.

M3 - Meeting Abstract

VL - 44

JO - European respiratory journal. Supplement

JF - European respiratory journal. Supplement

SN - 0904-1850

IS - Suppl. 58

M1 - P4751

ER -