Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging

Mark E. Lobatto, Claudia Calcagno, Antoine Millon, Max L. Senders, Francois Fay, Philip M. Robson, Sarayu Ramachandran, Tina Binderup, Maarten P.M. Paridaans, Steven Sensarn, Stephan Rogalla, Ronald E. Gordon, Luis Cardos, Gerrit Storm, Josbert Maarten Metselaar, Christopher H. Contag, Erik S.G. Stroes, Zahi A. Fayad, Willem J.M. Mulder

Research output: Contribution to journalArticleAcademicpeer-review

69 Citations (Scopus)

Abstract

Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and local drug delivery with nanoparticles, although the nanoparticle targeting mechanism for atherosclerosis has not yet been fully elucidated. Here we used in vivo and ex vivo multimodal imaging to examine permeability of the vessel wall and atherosclerotic plaque accumulation of fluorescently labeled liposomal nanoparticles in a rabbit model. We found a strong correlation between permeability as established by in vivo dynamic contrast enhanced magnetic resonance imaging and nanoparticle plaque accumulation with subsequent nanoparticle distribution throughout the vessel wall. These key observations will enable the development of nanotherapeutic strategies for atherosclerosis
Original languageEnglish
Pages (from-to)1837-1847
JournalACS nano
Volume9
Issue number2
DOIs
Publication statusPublished - 2015

Keywords

  • IR-99646
  • METIS-315198

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