Atrial trans-septal thrombus in massive pulmonary embolism salvaged by prolonged extracorporeal life support after thrombo-embolectomy. A bridge to right-sided cardiovascular adaptation

Thijs S.R. Delnoij*, Ryan E. Accord, Patrick W. Weerwind, Dirk W. Donker

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

15 Citations (Scopus)

Abstract

Massive pulmonary embolism poses a therapeutic challenge, especially when thrombolytics are controversial. We describe the complicated course of an exceptional case of massive pulmonary embolism exhibiting paradoxic embolization with a thrombus lodged in the foramen ovale. Thrombolysis was considered contraindicated and surgical intervention was performed. Postoperatively, persistent pulmonary hypertension and impending right ventricular (RV) failure necessitated the initiation of extracorporeal life support (ELS), accompanied by therapeutic heparinization, inhaled nitric oxide, levosimendan and sildenafil. On day 8, the patient was successfully weaned from ELS with excellent neurological recovery and virtual normalization of RV pressures and dimensions. (Contra-) indications for thrombolysis and surgical embolectomy are reviewed. The intriguing role of ELS in conjunction with therapeutic heparinization and pharmacological unloading of the right-sided vasculature and the RV is discussed.

Original languageEnglish
Pages (from-to)138-140
Number of pages3
JournalAcute Cardiac Care
Volume14
Issue number4
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

Keywords

  • Extracorporeal life support
  • Massive pulmonary embolism
  • Pulmonary hypertension
  • Right ventricular failure
  • Sub-acute pulmonary embolism
  • Veno-arterial extracorporeal membrane oxygenation

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