Autologous chondrocyte implantation versus microfracture for knee cartilage injury: a prospective randomized trial, with 2-year follow-up

Dieter van Assche (Corresponding Author), Filip Staes, Danny van Caspel, Johan Vanlauwe, Johan Bellemans, Daniël B. Saris, Frank P. Luyten

    Research output: Contribution to journalArticleAcademicpeer-review

    95 Citations (Scopus)

    Abstract

    The objective was to evaluate the functional performance over a 2-year period following autologous chondrocyte implantation (ACI) in an open knee procedure compared to microfracture. Objective functional outcome was studied as secondary analysis in a subgroup of patients, in a randomized clinical trial, with concealed allocation and independent evaluators. Sixty-seven patients with local cartilage defect, with a mean size of 2.4 cm² (SD 1.5) of the femoral condyle of the knee were included. Thirty-three patients underwent the microfracture and 34 the ACI procedure. An identical rehabilitation protocol was implemented for both groups. Active knee flexion and extension range, anterior laxity, knee extension strength (concentric at 60°/s) and single leg hop performance (single hop, crossover triple hop and 6 m timed hop test) were evaluated pre-surgery and at 6, 9,12 and 24 months post-surgery. We calculated the symmetry index for individual and four performance tests pooled. Mixed linear model analyses were used with confidence interval set at 95%. The change over 2 years for the pooled performance-based tests was comparable between the two treatment arms. At 2 years, 70% (38/54) of all patients returned to >85% symmetry in overall functional performance. A decrease in functional performance at 6 months following ACI resulted in slower recovery at 9 and 12 months compared to microfracture. Rehabilitation following both cartilage repair procedures is a lengthy process. At 2 years after surgery, ACI patients have similar overall functional outcome compared to microfracture patients.
    Original languageEnglish
    Pages (from-to)486-495
    JournalKnee surgery, sports traumatology, arthroscopy
    Volume18
    Issue number4
    DOIs
    Publication statusPublished - 2010

    Keywords

    • Cartilage
    • Treatment outcome
    • Surgery
    • Physical therapy
    • Knee
    • Exercise

    Fingerprint Dive into the research topics of 'Autologous chondrocyte implantation versus microfracture for knee cartilage injury: a prospective randomized trial, with 2-year follow-up'. Together they form a unique fingerprint.

    Cite this