Automated analysis of contrast enhancement in breast MRI lesions using mean shift clustering for ROI selection

Mark J. Stoutjesdijk*, Jeroen Veltman, Henkjan Huisman, Nico Karssemeijer, Jelle O. Barentsz, Johan G. Blickman, Carla Boetes

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)


Purpose: To evaluate a new method for automated determination of a region of interest (ROI) for the analysis of contrast enhancement in breast MRI. Materials and Methods: Mean shift multidimensional clustering (MS-MDC) was employed to divide 92 lesions into several spatially contiguous clusters each, based on multiple enhancement parameters. The ROIs were defined as the clusters with the highest probability of malignancy. The performance of enhancement analysis within these ROIs was estimated using the area under the receiver operator characteristic curve (AUC), and compared against a radiologist's final assessment and a classifier using histogram analysis (HA). For HA, the first, second, and third quartiles were evaluated. Results: MS-MDC resulted in AUC = 0.88 with a 95% confidence interval (CI) of 0.81-0.95. The AUC for the radiologist's assessment was 0.93 (95%CI = 0.87-0.97). Best HA performance was found using the first quartile, with AUC = 0.79 (95%CI = 0.69-0.88). There was no significant difference between MS-MDC and the radiologist (P = 0.40). The improvement of MS-MDC over HA was significant (P = 0.018). Conclusion: Mean shift clustering followed by automated selection of the most suspicious cluster resulted in accurate ROIs in breast MRI lesions.

Original languageEnglish
Pages (from-to)606-614
Number of pages9
JournalJournal of magnetic resonance imaging
Issue number3
Publication statusPublished - 1 Sep 2007
Externally publishedYes


  • Breast
  • CAD
  • Clustering
  • Mean shift
  • MRI


Dive into the research topics of 'Automated analysis of contrast enhancement in breast MRI lesions using mean shift clustering for ROI selection'. Together they form a unique fingerprint.

Cite this