Azacalixphyrins as NIR photoacoustic contrast agents

Lucien Lavaud; Simon Pascal; Khaled Metwally; Damien Gasteau; Anabela Da Silva; Zhongrui Chen; Mourad Elhabiri; Gabriel Canard; Denis Jacquemin; Olivier Siri

doi:10.1039/C8CC05851B

Azacalixphyrins as NIR photoacoustic contrast agents

Lucien Lavaud, Simon Pascal^*, Khaled Metwally, Damien Gasteau, Anabela Da Silva, Zhongrui Chen, Mourad Elhabiri, Gabriel Canard, Denis Jacquemin, Olivier Siri

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

Near-infrared (NIR) azacalixphyrins bearing aryl substituents strongly impacting the physico-chemical properties of the macrocycles were designed, enabling hyperchromic and bathochromic shifts of the absorption compared to their N-alkylated analogues. This engineering enhances the photoacoustic response under NIR excitation, making azacalixphyrins promising organic contrast agents that reach the 800-1000 nm range.

Original language	English
Pages (from-to)	12365-12368
Number of pages	4
Journal	Chemical communications
Volume	54
Issue number	87
DOIs	https://doi.org/10.1039/C8CC05851B
Publication status	Published - 1 Jan 2018
Externally published	Yes

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T1 - Azacalixphyrins as NIR photoacoustic contrast agents

AU - Lavaud, Lucien

AU - Pascal, Simon

AU - Metwally, Khaled

AU - Gasteau, Damien

AU - Da Silva, Anabela

AU - Chen, Zhongrui

AU - Elhabiri, Mourad

AU - Canard, Gabriel

AU - Jacquemin, Denis

AU - Siri, Olivier

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Near-infrared (NIR) azacalixphyrins bearing aryl substituents strongly impacting the physico-chemical properties of the macrocycles were designed, enabling hyperchromic and bathochromic shifts of the absorption compared to their N-alkylated analogues. This engineering enhances the photoacoustic response under NIR excitation, making azacalixphyrins promising organic contrast agents that reach the 800-1000 nm range.

AB - Near-infrared (NIR) azacalixphyrins bearing aryl substituents strongly impacting the physico-chemical properties of the macrocycles were designed, enabling hyperchromic and bathochromic shifts of the absorption compared to their N-alkylated analogues. This engineering enhances the photoacoustic response under NIR excitation, making azacalixphyrins promising organic contrast agents that reach the 800-1000 nm range.

UR - https://www.scopus.com/pages/publications/85055635019

U2 - 10.1039/C8CC05851B

DO - 10.1039/C8CC05851B

M3 - Article

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SP - 12365

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JO - Chemical communications

JF - Chemical communications

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ER -

Azacalixphyrins as NIR photoacoustic contrast agents

Abstract

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