Background-free nonlinear microspectroscopy with vibrational molecular interferometry

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Abstract

We demonstrate a method for performing nonlinear microspectroscopy that provides an intuitive and unified description of the various signal contributions, and allows the direct extraction of the vibrational response. Three optical fields create a pair of Stokes Raman pathways that interfere in the same vibrational state. Frequency modulating one of the fields leads to amplitude modulations on all of the fields. This vibrational molecular interferometry (VMI) technique allows imaging at high speed free of non-resonant background, and is able to distinguish between electronic and vibrational contributions to the total signal
Original languageEnglish
Title of host publicationMultiphoton Microscopy in the Biomedical Sciences XII
Subtitle of host publication22–24 January 2012, San Francisco, California, United States
EditorsAmmasi Periasamy, Karsten König, Peter T.C. So
PublisherSPIE
ISBN (Print)9780819488695
DOIs
Publication statusPublished - 9 Feb 2012
EventSPIE BiOS 2012 - The Moscone Center, San Francisco, United States
Duration: 21 Jan 201226 Jan 2012

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume8226
ISSN (Print)0277-786X

Conference

ConferenceSPIE BiOS 2012
CountryUnited States
CitySan Francisco
Period21/01/1226/01/12

Keywords

  • METIS-286037
  • IR-84664

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    Garbacik, E. T., Korterik, J. P., Otto, C., Mukamel, S., Herek, J. L., & Offerhaus, H. L. (2012). Background-free nonlinear microspectroscopy with vibrational molecular interferometry. In A. Periasamy, K. König, & P. T. C. So (Eds.), Multiphoton Microscopy in the Biomedical Sciences XII: 22–24 January 2012, San Francisco, California, United States [822605] (Proceedings of SPIE; Vol. 8226). SPIE. https://doi.org/10.1117/12.908158