Background reduction in a young interferometer biosensor

H. K P Mulder, V. Subramaniam, J. S. Kanger

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Integrated optical Young interferometer (IOYI) biosensors are among the most sensitive label-free biosensors. Detection limits are in the range of 20 fg/mm2. The applicability of these sensors is however strongly hampered by the large background that originates from both bulk refractive index changes and non-specific binding of molecules to the sensor surface. In this contribution we demonstrate a new method that allows us to separate the bulk background from the analyte signal. We show theoretical analysis and preliminary proof-of-principle experimental data, where binding of protein A is discriminated from a bulk refractive index change induced by D-Glucose, using multiple wavelengths. We anticipate that this method will increase the general applicability of IOYI sensors.

Original languageEnglish
Title of host publicationOptical Sensors, 2014
PublisherOptical Society of America
ISBN (Electronic)9781557528209
Publication statusPublished - 21 Jul 2014
EventOptical Sensors, SENSORS 2014 - Barcelona , Spain
Duration: 27 Jul 201431 Jul 2014
https://www.osa.org/en-us/meetings/osa_meeting_archives/2014/optical_sensors/

Conference

ConferenceOptical Sensors, SENSORS 2014
Abbreviated titleSENSORS 2014
CountrySpain
CityBarcelona
Period27/07/1431/07/14
Internet address

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    Mulder, H. K. P., Subramaniam, V., & Kanger, J. S. (2014). Background reduction in a young interferometer biosensor. In Optical Sensors, 2014 [107778] Optical Society of America.