Bacterial viability on chemically modified silicon nanowire arrays

A. Susarrey-Arce*, I. Sorzabal-Bellido, A. Oknianska, F. McBride, A.J. Beckett, J.G.E. Gardeniers, R. Raval, R.M. Tiggelaar, Y.A. Diaz Fernandez

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)
24 Downloads (Pure)


The global threat of antimicrobial resistance is driving an urgent need for novel antimicrobial strategies. Functional surfaces are essential to prevent spreading of infection and reduce surface contamination. In this study we have fabricated and characterized multiscale-functional nanotopographies with three levels of functionalization: (1) nanostructure topography in the form of silicon nanowires, (2) covalent chemical modification with (3-aminopropyl)triethoxysilane, and (3) incorporation of chlorhexidine digluconate. Cell viability assays were carried out on two model microorganisms E. coli and S. aureus over these nanotopographic surfaces. Using SEM we have identified two growth modes producing distinctive multicellular structures, i.e. in plane growth for E. coli and out of plane growth for S. aureus. We have also shown that these chemically modified SiNWs arrays are effective in reducing the number of planktonic and surface-attached microorganisms.

Original languageEnglish
Pages (from-to)3104-3112
Number of pages9
JournalJournal of materials chemistry. B: materials for biology and medicine
Issue number18
Publication statusPublished - 2016


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