Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein

Christian Blum; Mireille M.A.E. Claessens

doi:10.1016/j.tibs.2025.02.001

Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein

Christian Blum^*
, Mireille M.A.E. Claessens^*

^*Corresponding author for this work

Nanobiophysics

Research output: Contribution to journal › Short survey › Academic › peer-review

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Abstract

A recent report by Makasewicz et al. delineates how α-synuclein (αSyn) membrane-binding modes drive amyloid formation. Their in vitro data reveal a lipid-to-protein (L/P) ratio tipping point influencing fibril formation. Preliminary validation from existing literature supports that these findings are also relevant in cellular contexts, informing potential new disease-modulating strategies.

Original language	English
Pages (from-to)	285-286
Number of pages	2
Journal	Trends in Biochemical Sciences
Volume	50
Issue number	4
Early online date	25 Feb 2025
DOIs	https://doi.org/10.1016/j.tibs.2025.02.001
Publication status	Published - Apr 2025

Keywords

2025 OA procedure
Lipid membranes
Protein aggregation
Protein–membrane interactions
Vesicles
α-Synuclein (αSyn)
Amyloid

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10.1016/j.tibs.2025.02.001

ArticleFinal published version, 363 KBLicence: Taverne

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title = "Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein",

abstract = "A recent report by Makasewicz et al. delineates how α-synuclein (αSyn) membrane-binding modes drive amyloid formation. Their in vitro data reveal a lipid-to-protein (L/P) ratio tipping point influencing fibril formation. Preliminary validation from existing literature supports that these findings are also relevant in cellular contexts, informing potential new disease-modulating strategies.",

keywords = "2025 OA procedure, Lipid membranes, Protein aggregation, Protein–membrane interactions, Vesicles, α-Synuclein (αSyn), Amyloid",

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KW - 2025 OA procedure

KW - Lipid membranes

KW - Protein aggregation

KW - Protein–membrane interactions

KW - Vesicles

KW - α-Synuclein (αSyn)

KW - Amyloid

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DO - 10.1016/j.tibs.2025.02.001

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JO - Trends in Biochemical Sciences

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Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein

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Keywords

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