TY - JOUR
T1 - Benzodifurans for biomedical applications
T2 - BZ4, a selective anti-proliferative and anti-amyloid lead compound
AU - Vicidomini, Caterina
AU - Cioffi, Federica
AU - Broersen, Kerensa
AU - Roviello, Valentina
AU - Riccardi, Claudia
AU - Montesarchio, Daniela
AU - Capasso, Domenica
AU - Gaetano, Sonia Di
AU - Musumeci, Domenica
AU - Roviello, Giovanni N.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Aim: Our goal is to evaluate benzodifuran-based scaffolds for biomedical applications. Methodology: We here explored the anticancer and anti-amyloid activities of a novel compound (BZ4) in comparison with other known benzodifuran analogs, previously studied in our group, and we have explored its ability to interact with different DNA model systems. Results: BZ4 shows antiproliferative activity on different cancer cells; does not affect noncancerous control cells and alters the aggregation properties of β-amyloid, as ascertained by circular dichroism, fluorescence spectroscopy and scanning electron microscopy analysis. An overall, qualitative picture on the mechanistic aspects related to the biological activities is discussed in light of the dynamic light scattering, UV, circular dichroism and fluorescence data, as well as of the metal ion-binding properties of BZ4.
AB - Aim: Our goal is to evaluate benzodifuran-based scaffolds for biomedical applications. Methodology: We here explored the anticancer and anti-amyloid activities of a novel compound (BZ4) in comparison with other known benzodifuran analogs, previously studied in our group, and we have explored its ability to interact with different DNA model systems. Results: BZ4 shows antiproliferative activity on different cancer cells; does not affect noncancerous control cells and alters the aggregation properties of β-amyloid, as ascertained by circular dichroism, fluorescence spectroscopy and scanning electron microscopy analysis. An overall, qualitative picture on the mechanistic aspects related to the biological activities is discussed in light of the dynamic light scattering, UV, circular dichroism and fluorescence data, as well as of the metal ion-binding properties of BZ4.
KW - anti-amyloid
KW - anticancer
KW - synthesis
UR - http://www.scopus.com/inward/record.url?scp=85063617809&partnerID=8YFLogxK
U2 - 10.4155/fmc-2018-0473
DO - 10.4155/fmc-2018-0473
M3 - Article
AN - SCOPUS:85063617809
VL - 11
SP - 285
EP - 302
JO - Future Medicinal Chemistry
JF - Future Medicinal Chemistry
SN - 1756-8919
IS - 4
ER -