TY - JOUR
T1 - Bioactive calcium phosphate coatings applied to flexible poly(carbonate urethane) foils
AU - Farjam, P.
AU - Luckabauer, M.
AU - Vries, E.G. de
AU - Rangel, V.R.
AU - Hekman, E.E.G.
AU - Verkerke, G.J.
AU - Rouwkema, J.
N1 - Funding Information:
This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 863183 .
Publisher Copyright:
© 2023 The Authors
PY - 2023/10/15
Y1 - 2023/10/15
N2 - Long-term fixation of orthopaedic implants can be enhanced by tissue ingrowth techniques. As such, the deposition of a bioactive bone-like coating could be considered a promising method to facilitate the integration of implants onto bone tissue. In this study, we identified the optimized osteo-conductive Calcium Phosphate (CaP) coating parameters for deposition on PolyCarbonate-Urethane (PCU) foils. The oxygen plasma surface-activated PCU specimens were suspended in simulated body fluid (SBF) and supersaturated SBFs for 4 h, 8 h, 24 h, or 6 days at a temperature of 20 °C, 37 °C, or 50 °C. This resulted in semi-crystalline CaP coatings on a thin flexible foil via a one-step low-temperature aqueous technique. The deposited CaP coatings demonstrated high stability and remained intact upon bending deformation. According to the in vitro cell assessments, the conducted CaP coatings did not influence cell viability nor cell proliferation compared to the bare PCU substrate. In addition, the deposited CaP coatings enhanced the cell-mediated calcium deposition. All in all, this paper demonstrates a promising method to apply stable bioactive coatings to flexible PCU foils, which can be a promising strategy for the enhanced integration of PCU implants onto bone.
AB - Long-term fixation of orthopaedic implants can be enhanced by tissue ingrowth techniques. As such, the deposition of a bioactive bone-like coating could be considered a promising method to facilitate the integration of implants onto bone tissue. In this study, we identified the optimized osteo-conductive Calcium Phosphate (CaP) coating parameters for deposition on PolyCarbonate-Urethane (PCU) foils. The oxygen plasma surface-activated PCU specimens were suspended in simulated body fluid (SBF) and supersaturated SBFs for 4 h, 8 h, 24 h, or 6 days at a temperature of 20 °C, 37 °C, or 50 °C. This resulted in semi-crystalline CaP coatings on a thin flexible foil via a one-step low-temperature aqueous technique. The deposited CaP coatings demonstrated high stability and remained intact upon bending deformation. According to the in vitro cell assessments, the conducted CaP coatings did not influence cell viability nor cell proliferation compared to the bare PCU substrate. In addition, the deposited CaP coatings enhanced the cell-mediated calcium deposition. All in all, this paper demonstrates a promising method to apply stable bioactive coatings to flexible PCU foils, which can be a promising strategy for the enhanced integration of PCU implants onto bone.
KW - UT-Hybrid-D
U2 - 10.1016/j.surfcoat.2023.129838
DO - 10.1016/j.surfcoat.2023.129838
M3 - Article
SN - 0257-8972
VL - 470
JO - Surface and coatings technology
JF - Surface and coatings technology
M1 - 129838
ER -