Biocompatible, accurate, and fully autonomous: a sperm-driven micro-bio-robot

Islam S.M. Khalil; Veronika Magdanz; Samuel Sanchez; Oliver G. Schmidt; Sarthak Misra

doi:10.1007/s12213-014-0077-9

Biocompatible, accurate, and fully autonomous: a sperm-driven micro-bio-robot

Islam S.M. Khalil^*
, Veronika Magdanz
, Samuel Sanchez
, Oliver G. Schmidt
, Sarthak Misra

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

38 Citations (Scopus)

Abstract

We study the magnetic-based motion control of a sperm-flagella driven Micro-Bio-Robot (MBR), and demonstrate precise point-to-point closed-loop motion control under the influence of the controlled magnetic field lines. This MBR consists of a bovine spermatozoon that is captured inside Ti/Fe nanomembranes. The nanomembranes are rolled-up into a 50 μm long microtube with a diameter of 5-8 μm. Our MBR is self-propelled by the sperm cell and guided using the magnetic torque exerted on the magnetic dipole of its rolled-up microtube. The self-propulsion force provided by the sperm cell allows the MBR to move at an average velocity of 25 ±10 μm/s towards a reference position, whereas the magnetic dipole moment and the controlled weak magnetic fields (approximately 1.39 mT) allow for the localization of the MBR within the vicinity of reference positions with an average region-of-convergence of 90 ±40μm. In addition, we experimentally demonstrate the guided motion of the MBR towards a magnetic microparticle with applications towards targeted drug delivery and microactuation.

Original language	English
Pages (from-to)	79-86
Number of pages	8
Journal	Journal of micro-bio robotics
Volume	9
Issue number	3-4
DOIs	https://doi.org/10.1007/s12213-014-0077-9
Publication status	Published - 1 Jan 2014

Keywords

Closed-loop
Magnetic guidance
Micro-bio-robot
Motion control
Self-propulsion
Sperm cells

Access to Document

10.1007/s12213-014-0077-9

Cite this

@article{d6041376435d4c0f8df7e4a9feeb269a,

title = "Biocompatible, accurate, and fully autonomous: a sperm-driven micro-bio-robot",

abstract = "We study the magnetic-based motion control of a sperm-flagella driven Micro-Bio-Robot (MBR), and demonstrate precise point-to-point closed-loop motion control under the influence of the controlled magnetic field lines. This MBR consists of a bovine spermatozoon that is captured inside Ti/Fe nanomembranes. The nanomembranes are rolled-up into a 50 μm long microtube with a diameter of 5-8 μm. Our MBR is self-propelled by the sperm cell and guided using the magnetic torque exerted on the magnetic dipole of its rolled-up microtube. The self-propulsion force provided by the sperm cell allows the MBR to move at an average velocity of 25 ±10 μm/s towards a reference position, whereas the magnetic dipole moment and the controlled weak magnetic fields (approximately 1.39 mT) allow for the localization of the MBR within the vicinity of reference positions with an average region-of-convergence of 90 ±40μm. In addition, we experimentally demonstrate the guided motion of the MBR towards a magnetic microparticle with applications towards targeted drug delivery and microactuation.",

keywords = "Closed-loop, Magnetic guidance, Micro-bio-robot, Motion control, Self-propulsion, Sperm cells",

author = "Khalil, \{Islam S.M.\} and Veronika Magdanz and Samuel Sanchez and Schmidt, \{Oliver G.\} and Sarthak Misra",

note = "Funding Information: Acknowledgments The authors acknowledge the funding from MIRA-Institute for Biomedical Technology and Technical Medicine, University of Twente. The research leading to these results has also received funding from the Volkswagen Foundation (\# 86 362) and the European Research Council under the European Unions Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement No. 311529. Publisher Copyright: {\textcopyright} 2014, Springer-Verlag Berlin Heidelberg.",

year = "2014",

month = jan,

day = "1",

doi = "10.1007/s12213-014-0077-9",

language = "English",

volume = "9",

pages = "79--86",

journal = "Journal of micro-bio robotics",

issn = "2194-6418",

publisher = "Springer",

number = "3-4",

}

TY - JOUR

T1 - Biocompatible, accurate, and fully autonomous

T2 - a sperm-driven micro-bio-robot

AU - Khalil, Islam S.M.

AU - Magdanz, Veronika

AU - Sanchez, Samuel

AU - Schmidt, Oliver G.

AU - Misra, Sarthak

N1 - Funding Information: Acknowledgments The authors acknowledge the funding from MIRA-Institute for Biomedical Technology and Technical Medicine, University of Twente. The research leading to these results has also received funding from the Volkswagen Foundation (# 86 362) and the European Research Council under the European Unions Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement No. 311529. Publisher Copyright: © 2014, Springer-Verlag Berlin Heidelberg.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - We study the magnetic-based motion control of a sperm-flagella driven Micro-Bio-Robot (MBR), and demonstrate precise point-to-point closed-loop motion control under the influence of the controlled magnetic field lines. This MBR consists of a bovine spermatozoon that is captured inside Ti/Fe nanomembranes. The nanomembranes are rolled-up into a 50 μm long microtube with a diameter of 5-8 μm. Our MBR is self-propelled by the sperm cell and guided using the magnetic torque exerted on the magnetic dipole of its rolled-up microtube. The self-propulsion force provided by the sperm cell allows the MBR to move at an average velocity of 25 ±10 μm/s towards a reference position, whereas the magnetic dipole moment and the controlled weak magnetic fields (approximately 1.39 mT) allow for the localization of the MBR within the vicinity of reference positions with an average region-of-convergence of 90 ±40μm. In addition, we experimentally demonstrate the guided motion of the MBR towards a magnetic microparticle with applications towards targeted drug delivery and microactuation.

AB - We study the magnetic-based motion control of a sperm-flagella driven Micro-Bio-Robot (MBR), and demonstrate precise point-to-point closed-loop motion control under the influence of the controlled magnetic field lines. This MBR consists of a bovine spermatozoon that is captured inside Ti/Fe nanomembranes. The nanomembranes are rolled-up into a 50 μm long microtube with a diameter of 5-8 μm. Our MBR is self-propelled by the sperm cell and guided using the magnetic torque exerted on the magnetic dipole of its rolled-up microtube. The self-propulsion force provided by the sperm cell allows the MBR to move at an average velocity of 25 ±10 μm/s towards a reference position, whereas the magnetic dipole moment and the controlled weak magnetic fields (approximately 1.39 mT) allow for the localization of the MBR within the vicinity of reference positions with an average region-of-convergence of 90 ±40μm. In addition, we experimentally demonstrate the guided motion of the MBR towards a magnetic microparticle with applications towards targeted drug delivery and microactuation.

KW - Closed-loop

KW - Magnetic guidance

KW - Micro-bio-robot

KW - Motion control

KW - Self-propulsion

KW - Sperm cells

UR - https://www.scopus.com/pages/publications/84919713067

U2 - 10.1007/s12213-014-0077-9

DO - 10.1007/s12213-014-0077-9

M3 - Article

AN - SCOPUS:84919713067

SN - 2194-6418

VL - 9

SP - 79

EP - 86

JO - Journal of micro-bio robotics

JF - Journal of micro-bio robotics

IS - 3-4

ER -

Biocompatible, accurate, and fully autonomous: a sperm-driven micro-bio-robot

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this