Biocompatible single-chain polymer nanoparticles for drug deliverya dual approach

A. Pia P. Kröger, Naomi M. Hamelmann, Alberto Juan, Saskia Lindhoud, Jos M.J. Paulusse* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)
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Single-chain polymer nanoparticles (SCNPs) are protein-inspired materials based on intramolecularly cross-linked polymer chains. We report here the development of SCNPs as uniquely sized nanocarriers that are capable of drug encapsulation independent of the polarity of the employed medium. Synthetic routes are presented for SCNP preparation in both organic and aqueous environments. Importantly, the SCNPs in organic media were successfully rendered water soluble, resulting in two complementary pathways toward water-soluble SCNPs with comparable resultant physicochemical characteristics. The solvatochromic dye Nile red was successfully encapsulated inside the SCNPs following both pathways, enabling probing of the SCNP interior. Moreover, the antibiotic rifampicin was encapsulated in organic medium, the loaded nanocarriers were rendered water soluble, and a controlled release of rifampicin was evidenced. The absence of discernible cytotoxic effects and promising cellular uptake behavior bode well for the application of SCNPs in controlled therapeutics delivery.

Original languageEnglish
Pages (from-to)30946-30951
Number of pages6
JournalACS Applied Materials and Interfaces
Issue number37
Publication statusPublished - 19 Sep 2018


  • UT-Hybrid-D
  • Drug encapsulation
  • Single-chain polymer nanoparticles
  • Thiol polymers
  • Thiol-Michael addition
  • Controlled drug delivery
  • controlled drug delivery
  • single-chain polymer nanoparticles
  • drug encapsulation
  • thiol-Michael addition
  • thiol polymers


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