Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

Dennis Lensen; E.C. Gelderblom; Dennis M. Vriezema; P.G.M. Marmottant; Nicolaas Jacobus Joseph Verdonschot; Michel Versluis; N. de Jong; Jan C.M. van Hest

doi:10.1039/C1SM05324H

Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

Dennis Lensen, E.C. Gelderblom, Dennis M. Vriezema, P.G.M. Marmottant, Nicolaas Jacobus Joseph Verdonschot, Michel Versluis, N. de Jong, Jan C.M. van Hest

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Abstract

A series of hollow biodegradable polymeric microcapsules were prepared, of which their susceptibility to ultrasound was used for triggered release. High speed imaging of the ultrasound experiments showed a strong correlation between the acoustic pressure needed to activate these microcapsules and their shell thickness to diameter ratio. Based on this information a selective triggering of capsules with two different shell thickness to diameter ratios was successfully performed. The capsules were mixed in a single system and were activated independently from each other by a differentiation in acoustic pressure levels. This application is of great interest in the field of drug delivery, since this system allows for localized multiple drug releases in a selective fashion

Original language	English
Pages (from-to)	5417-5422
Number of pages	6
Journal	Soft matter
Volume	7
Issue number	11
DOIs	https://doi.org/10.1039/C1SM05324H
Publication status	Published - 2011

Keywords

METIS-275449
IR-79085

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10.1039/C1SM05324H

http://pubs.rsc.org/en/Content/ArticleLanding/2011/SM/c1sm05324h

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title = "Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release",

abstract = "A series of hollow biodegradable polymeric microcapsules were prepared, of which their susceptibility to ultrasound was used for triggered release. High speed imaging of the ultrasound experiments showed a strong correlation between the acoustic pressure needed to activate these microcapsules and their shell thickness to diameter ratio. Based on this information a selective triggering of capsules with two different shell thickness to diameter ratios was successfully performed. The capsules were mixed in a single system and were activated independently from each other by a differentiation in acoustic pressure levels. This application is of great interest in the field of drug delivery, since this system allows for localized multiple drug releases in a selective fashion",

keywords = "METIS-275449, IR-79085",

author = "Dennis Lensen and E.C. Gelderblom and Vriezema, {Dennis M.} and P.G.M. Marmottant and Verdonschot, {Nicolaas Jacobus Joseph} and Michel Versluis and {de Jong}, N. and {van Hest}, {Jan C.M.}",

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T1 - Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

AU - Lensen, Dennis

AU - Gelderblom, E.C.

AU - Vriezema, Dennis M.

AU - Marmottant, P.G.M.

AU - Verdonschot, Nicolaas Jacobus Joseph

AU - Versluis, Michel

AU - de Jong, N.

AU - van Hest, Jan C.M.

PY - 2011

Y1 - 2011

N2 - A series of hollow biodegradable polymeric microcapsules were prepared, of which their susceptibility to ultrasound was used for triggered release. High speed imaging of the ultrasound experiments showed a strong correlation between the acoustic pressure needed to activate these microcapsules and their shell thickness to diameter ratio. Based on this information a selective triggering of capsules with two different shell thickness to diameter ratios was successfully performed. The capsules were mixed in a single system and were activated independently from each other by a differentiation in acoustic pressure levels. This application is of great interest in the field of drug delivery, since this system allows for localized multiple drug releases in a selective fashion

AB - A series of hollow biodegradable polymeric microcapsules were prepared, of which their susceptibility to ultrasound was used for triggered release. High speed imaging of the ultrasound experiments showed a strong correlation between the acoustic pressure needed to activate these microcapsules and their shell thickness to diameter ratio. Based on this information a selective triggering of capsules with two different shell thickness to diameter ratios was successfully performed. The capsules were mixed in a single system and were activated independently from each other by a differentiation in acoustic pressure levels. This application is of great interest in the field of drug delivery, since this system allows for localized multiple drug releases in a selective fashion

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KW - IR-79085

U2 - 10.1039/C1SM05324H

DO - 10.1039/C1SM05324H

M3 - Article

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VL - 7

SP - 5417

EP - 5422

JO - Soft matter

JF - Soft matter

IS - 11

ER -

Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

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Keywords

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