Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

Dennis Lensen, E.C. Gelderblom, Dennis M. Vriezema, P.G.M. Marmottant, Nicolaas Jacobus Joseph Verdonschot, Michel Versluis, N. de Jong, Jan C.M. van Hest

Research output: Contribution to journalArticleAcademicpeer-review

63 Citations (Scopus)

Abstract

A series of hollow biodegradable polymeric microcapsules were prepared, of which their susceptibility to ultrasound was used for triggered release. High speed imaging of the ultrasound experiments showed a strong correlation between the acoustic pressure needed to activate these microcapsules and their shell thickness to diameter ratio. Based on this information a selective triggering of capsules with two different shell thickness to diameter ratios was successfully performed. The capsules were mixed in a single system and were activated independently from each other by a differentiation in acoustic pressure levels. This application is of great interest in the field of drug delivery, since this system allows for localized multiple drug releases in a selective fashion
Original languageEnglish
Pages (from-to)5417-5422
Number of pages6
JournalSoft matter
Volume7
Issue number11
DOIs
Publication statusPublished - 2011

Keywords

  • METIS-275449
  • IR-79085

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