Abstract
Hydrophilic fluorescein isothiocyanate-dextran (FD, mol. weight 4000 g/mol) could be readily incorporated in polymersomes (PS) made of different amphiphilic biodegradable block copolymers based on PEG-PDLLA, PEG-PCL, and PEG-PTMC. The FD release from these polymersomes in PBS at 37 °C was complete within approximately 10 days. Both the length of the hydrophobic block as well as the type of the hydrophobic block have a major influence on the release rate of FD from the PS, while the hydrophilic block length has only a minor influence on the release rate. For all systems the release of FD follows first order kinetics, confirming that the FD containing polymersome system is a membrane controlled reservoir system.
Original language | Undefined |
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Pages | e35-e36 |
DOIs | |
Publication status | Published - 2 Apr 2008 |
Event | 10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands Duration: 2 Apr 2008 → 4 Apr 2008 Conference number: 10 |
Conference
Conference | 10th European Symposium on Controlled Drug Delivery, ESCDD 2008 |
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Abbreviated title | ESCDD |
Country/Territory | Netherlands |
City | Noordwijk aan Zee |
Period | 2/04/08 → 4/04/08 |
Keywords
- IR-69433
- METIS-254630