Biodegradable polymersomes for controled drug release

W. Zhou, J. Feijen (Editor), W.E. Hennink (Editor), Jan Feijen, A.P. Sam (Editor)

Research output: Contribution to conferencePaper

Abstract

Hydrophilic fluorescein isothiocyanate-dextran (FD, mol. weight 4000 g/mol) could be readily incorporated in polymersomes (PS) made of different amphiphilic biodegradable block copolymers based on PEG-PDLLA, PEG-PCL, and PEG-PTMC. The FD release from these polymersomes in PBS at 37 °C was complete within approximately 10 days. Both the length of the hydrophobic block as well as the type of the hydrophobic block have a major influence on the release rate of FD from the PS, while the hydrophilic block length has only a minor influence on the release rate. For all systems the release of FD follows first order kinetics, confirming that the FD containing polymersome system is a membrane controlled reservoir system.
Original languageUndefined
Pagese35-e36
DOIs
Publication statusPublished - 2 Apr 2008
Event10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands
Duration: 2 Apr 20084 Apr 2008
Conference number: 10

Conference

Conference10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated titleESCDD
CountryNetherlands
CityNoordwijk aan Zee
Period2/04/084/04/08

Keywords

  • IR-69433
  • METIS-254630

Cite this

Zhou, W., Feijen, J. (Ed.), Hennink, W. E. (Ed.), Feijen, J., & Sam, A. P. (Ed.) (2008). Biodegradable polymersomes for controled drug release. e35-e36. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.022