Biodegradable polymersomes for controled drug release

W. Zhou, J. Feijen (Editor), W.E. Hennink (Editor), Jan Feijen, A.P. Sam (Editor)

Research output: Contribution to conferencePaperAcademic

Abstract

Hydrophilic fluorescein isothiocyanate-dextran (FD, mol. weight 4000 g/mol) could be readily incorporated in polymersomes (PS) made of different amphiphilic biodegradable block copolymers based on PEG-PDLLA, PEG-PCL, and PEG-PTMC. The FD release from these polymersomes in PBS at 37 °C was complete within approximately 10 days. Both the length of the hydrophobic block as well as the type of the hydrophobic block have a major influence on the release rate of FD from the PS, while the hydrophilic block length has only a minor influence on the release rate. For all systems the release of FD follows first order kinetics, confirming that the FD containing polymersome system is a membrane controlled reservoir system.
Original languageUndefined
Pagese35-e36
DOIs
Publication statusPublished - 2 Apr 2008
Event10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands
Duration: 2 Apr 20084 Apr 2008
Conference number: 10

Conference

Conference10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated titleESCDD
CountryNetherlands
CityNoordwijk aan Zee
Period2/04/084/04/08

Keywords

  • IR-69433
  • METIS-254630

Cite this

Zhou, W., Feijen, J. (Ed.), Hennink, W. E. (Ed.), Feijen, J., & Sam, A. P. (Ed.) (2008). Biodegradable polymersomes for controled drug release. e35-e36. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.022
Zhou, W. ; Feijen, J. (Editor) ; Hennink, W.E. (Editor) ; Feijen, Jan ; Sam, A.P. (Editor). / Biodegradable polymersomes for controled drug release. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands.
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title = "Biodegradable polymersomes for controled drug release",
abstract = "Hydrophilic fluorescein isothiocyanate-dextran (FD, mol. weight 4000 g/mol) could be readily incorporated in polymersomes (PS) made of different amphiphilic biodegradable block copolymers based on PEG-PDLLA, PEG-PCL, and PEG-PTMC. The FD release from these polymersomes in PBS at 37 °C was complete within approximately 10 days. Both the length of the hydrophobic block as well as the type of the hydrophobic block have a major influence on the release rate of FD from the PS, while the hydrophilic block length has only a minor influence on the release rate. For all systems the release of FD follows first order kinetics, confirming that the FD containing polymersome system is a membrane controlled reservoir system.",
keywords = "IR-69433, METIS-254630",
author = "W. Zhou and J. Feijen and W.E. Hennink and Jan Feijen and A.P. Sam",
note = "Proceedings of the Tenth European Symposium on Controlled Drug Delivery ; null ; Conference date: 02-04-2008 Through 04-04-2008",
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doi = "10.1016/j.jconrel.2008.09.022",
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}

Zhou, W, Feijen, J (ed.), Hennink, WE (ed.), Feijen, J & Sam, AP (ed.) 2008, 'Biodegradable polymersomes for controled drug release' Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands, 2/04/08 - 4/04/08, pp. e35-e36. https://doi.org/10.1016/j.jconrel.2008.09.022

Biodegradable polymersomes for controled drug release. / Zhou, W.; Feijen, J. (Editor); Hennink, W.E. (Editor); Feijen, Jan; Sam, A.P. (Editor).

2008. e35-e36 Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands.

Research output: Contribution to conferencePaperAcademic

TY - CONF

T1 - Biodegradable polymersomes for controled drug release

AU - Zhou, W.

AU - Feijen, Jan

A2 - Feijen, J.

A2 - Hennink, W.E.

A2 - Sam, A.P.

N1 - Proceedings of the Tenth European Symposium on Controlled Drug Delivery

PY - 2008/4/2

Y1 - 2008/4/2

N2 - Hydrophilic fluorescein isothiocyanate-dextran (FD, mol. weight 4000 g/mol) could be readily incorporated in polymersomes (PS) made of different amphiphilic biodegradable block copolymers based on PEG-PDLLA, PEG-PCL, and PEG-PTMC. The FD release from these polymersomes in PBS at 37 °C was complete within approximately 10 days. Both the length of the hydrophobic block as well as the type of the hydrophobic block have a major influence on the release rate of FD from the PS, while the hydrophilic block length has only a minor influence on the release rate. For all systems the release of FD follows first order kinetics, confirming that the FD containing polymersome system is a membrane controlled reservoir system.

AB - Hydrophilic fluorescein isothiocyanate-dextran (FD, mol. weight 4000 g/mol) could be readily incorporated in polymersomes (PS) made of different amphiphilic biodegradable block copolymers based on PEG-PDLLA, PEG-PCL, and PEG-PTMC. The FD release from these polymersomes in PBS at 37 °C was complete within approximately 10 days. Both the length of the hydrophobic block as well as the type of the hydrophobic block have a major influence on the release rate of FD from the PS, while the hydrophilic block length has only a minor influence on the release rate. For all systems the release of FD follows first order kinetics, confirming that the FD containing polymersome system is a membrane controlled reservoir system.

KW - IR-69433

KW - METIS-254630

U2 - 10.1016/j.jconrel.2008.09.022

DO - 10.1016/j.jconrel.2008.09.022

M3 - Paper

SP - e35-e36

ER -

Zhou W, Feijen J, (ed.), Hennink WE, (ed.), Feijen J, Sam AP, (ed.). Biodegradable polymersomes for controled drug release. 2008. Paper presented at 10th European Symposium on Controlled Drug Delivery, ESCDD 2008, Noordwijk aan Zee, Netherlands. https://doi.org/10.1016/j.jconrel.2008.09.022