Biodegradable polymersomes for controled drug release

W. Zhou; J. Feijen; W.E. Hennink; Jan Feijen; A.P. Sam

doi:10.1016/j.jconrel.2008.09.022

Biodegradable polymersomes for controled drug release

W. Zhou
, J. Feijen (Editor)
, W.E. Hennink (Editor)
, Jan Feijen
, A.P. Sam (Editor)

Research output: Contribution to conference › Paper

1 Citation (Scopus)

4 Downloads (Pure)

Abstract

Hydrophilic fluorescein isothiocyanate-dextran (FD, mol. weight 4000 g/mol) could be readily incorporated in polymersomes (PS) made of different amphiphilic biodegradable block copolymers based on PEG-PDLLA, PEG-PCL, and PEG-PTMC. The FD release from these polymersomes in PBS at 37 °C was complete within approximately 10 days. Both the length of the hydrophobic block as well as the type of the hydrophobic block have a major influence on the release rate of FD from the PS, while the hydrophilic block length has only a minor influence on the release rate. For all systems the release of FD follows first order kinetics, confirming that the FD containing polymersome system is a membrane controlled reservoir system.

Original language	Undefined
Pages	e35-e36
DOIs	https://doi.org/10.1016/j.jconrel.2008.09.022
Publication status	Published - 2 Apr 2008
Event	10th European Symposium on Controlled Drug Delivery, ESCDD 2008 - Noordwijk aan Zee, Netherlands Duration: 2 Apr 2008 → 4 Apr 2008 Conference number: 10

Conference

Conference	10th European Symposium on Controlled Drug Delivery, ESCDD 2008
Abbreviated title	ESCDD
Country/Territory	Netherlands
City	Noordwijk aan Zee
Period	2/04/08 → 4/04/08

Keywords

IR-69433
METIS-254630

Access to Document

10.1016/j.jconrel.2008.09.022

Cite this

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title = "Biodegradable polymersomes for controled drug release",

abstract = "Hydrophilic fluorescein isothiocyanate-dextran (FD, mol. weight 4000 g/mol) could be readily incorporated in polymersomes (PS) made of different amphiphilic biodegradable block copolymers based on PEG-PDLLA, PEG-PCL, and PEG-PTMC. The FD release from these polymersomes in PBS at 37 °C was complete within approximately 10 days. Both the length of the hydrophobic block as well as the type of the hydrophobic block have a major influence on the release rate of FD from the PS, while the hydrophilic block length has only a minor influence on the release rate. For all systems the release of FD follows first order kinetics, confirming that the FD containing polymersome system is a membrane controlled reservoir system.",

keywords = "IR-69433, METIS-254630",

author = "W. Zhou and J. Feijen and W.E. Hennink and Jan Feijen and A.P. Sam",

note = "Proceedings of the Tenth European Symposium on Controlled Drug Delivery ; 10th European Symposium on Controlled Drug Delivery, ESCDD 2008 ; Conference date: 02-04-2008 Through 04-04-2008",

year = "2008",

month = apr,

day = "2",

doi = "10.1016/j.jconrel.2008.09.022",

language = "Undefined",

pages = "e35--e36",

}

TY - CONF

T1 - Biodegradable polymersomes for controled drug release

AU - Zhou, W.

AU - Feijen, Jan

A2 - Feijen, J.

A2 - Hennink, W.E.

A2 - Sam, A.P.

N1 - Conference code: 10

PY - 2008/4/2

Y1 - 2008/4/2

N2 - Hydrophilic fluorescein isothiocyanate-dextran (FD, mol. weight 4000 g/mol) could be readily incorporated in polymersomes (PS) made of different amphiphilic biodegradable block copolymers based on PEG-PDLLA, PEG-PCL, and PEG-PTMC. The FD release from these polymersomes in PBS at 37 °C was complete within approximately 10 days. Both the length of the hydrophobic block as well as the type of the hydrophobic block have a major influence on the release rate of FD from the PS, while the hydrophilic block length has only a minor influence on the release rate. For all systems the release of FD follows first order kinetics, confirming that the FD containing polymersome system is a membrane controlled reservoir system.

AB - Hydrophilic fluorescein isothiocyanate-dextran (FD, mol. weight 4000 g/mol) could be readily incorporated in polymersomes (PS) made of different amphiphilic biodegradable block copolymers based on PEG-PDLLA, PEG-PCL, and PEG-PTMC. The FD release from these polymersomes in PBS at 37 °C was complete within approximately 10 days. Both the length of the hydrophobic block as well as the type of the hydrophobic block have a major influence on the release rate of FD from the PS, while the hydrophilic block length has only a minor influence on the release rate. For all systems the release of FD follows first order kinetics, confirming that the FD containing polymersome system is a membrane controlled reservoir system.

KW - IR-69433

KW - METIS-254630

U2 - 10.1016/j.jconrel.2008.09.022

DO - 10.1016/j.jconrel.2008.09.022

M3 - Paper

SP - e35-e36

T2 - 10th European Symposium on Controlled Drug Delivery, ESCDD 2008

Y2 - 2 April 2008 through 4 April 2008

ER -