Biodegradable Protein Nanocontainers

Keti Piradashvili; Michael Fichter; Kristin Mohr; Stephan Gehring; Frederik R. Wurm; Katharina Landfester

doi:10.1021/bm5016915

Biodegradable Protein Nanocontainers

Keti Piradashvili, Michael Fichter, Kristin Mohr, Stephan Gehring, Frederik R. Wurm, Katharina Landfester

Research output: Contribution to journal › Article › Academic › peer-review

46 Citations (Scopus)

Abstract

The application of synthetic polymers for drug delivery often requires tremendous efforts to ensure biocompatibility and -degradation. To use the body's own substances can help to overcome these problems. Herein, we present the first synthesis of nanocontainers entirely composed of albumin proteins. These protein nanocontainers (PNCs) were loaded with hydrophilic compounds and release of the payload is triggered through natural lysis in vitro in human monocyte-derived dendritic cells (moDCs). No aggregation of PNCs in human blood plasma was observed, indicating stability for blood circulation. As the PNCs were readily taken up by moDCs, they are considered as a promising delivery platform for vaccination strategies and could minimize the risk of side effects caused by foreign carrier substances.

Original language	English
Pages (from-to)	815-821
Number of pages	7
Journal	Biomacromolecules
Volume	16
Issue number	3
DOIs	https://doi.org/10.1021/bm5016915
Publication status	Published - 9 Mar 2015
Externally published	Yes

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10.1021/bm5016915

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AU - Piradashvili, Keti

AU - Fichter, Michael

AU - Mohr, Kristin

AU - Gehring, Stephan

AU - Wurm, Frederik R.

AU - Landfester, Katharina

PY - 2015/3/9

Y1 - 2015/3/9

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AB - The application of synthetic polymers for drug delivery often requires tremendous efforts to ensure biocompatibility and -degradation. To use the body's own substances can help to overcome these problems. Herein, we present the first synthesis of nanocontainers entirely composed of albumin proteins. These protein nanocontainers (PNCs) were loaded with hydrophilic compounds and release of the payload is triggered through natural lysis in vitro in human monocyte-derived dendritic cells (moDCs). No aggregation of PNCs in human blood plasma was observed, indicating stability for blood circulation. As the PNCs were readily taken up by moDCs, they are considered as a promising delivery platform for vaccination strategies and could minimize the risk of side effects caused by foreign carrier substances.

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Biodegradable Protein Nanocontainers

Abstract

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