Bioengineered 3D Models to Recapitulate Tissue Fibrosis

Marta Sacchi, Ruchi Bansal*, Jeroen Rouwkema

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Fibrosis, characterized by progressive tissue stiffening resulting in organ failure, is a growing health problem affecting millions of people worldwide. Currently, therapeutic options for tissue fibrosis are severely limited and organ transplantation is the only effective treatment for the end-stage fibrotic diseases with inherent limitations. Recent advancements in engineered 3D in vitro human disease mimic models, recapitulating the tissue pathophysiology, have provided unique state-of-the-art platforms for: (i) understanding the biological mechanisms involved in the disease pathogenesis; and (ii) high-throughput and reproducible drug screening. This review focuses on the recent multidisciplinary developments made towards advanced 3D biomimetic fibrotic tissue (liver, kidney, and lung) models that combine highly precision manufacturing techniques with high cellular functionality and biophysical (mechanical) properties.

Original languageEnglish
JournalTrends in biotechnology
DOIs
Publication statusAccepted/In press - 15 Jan 2020

Fingerprint

Fibrosis
Tissue
Transplantation (surgical)
Biomimetics
Preclinical Drug Evaluations
Organ Transplantation
Medical problems
Liver
Screening
Throughput
Kidney
Mechanical properties
Lung
Health
Pharmaceutical Preparations
Therapeutics

Keywords

  • biofabrication
  • fibrosis
  • screening
  • self-assembly
  • tissue models

Cite this

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title = "Bioengineered 3D Models to Recapitulate Tissue Fibrosis",
abstract = "Fibrosis, characterized by progressive tissue stiffening resulting in organ failure, is a growing health problem affecting millions of people worldwide. Currently, therapeutic options for tissue fibrosis are severely limited and organ transplantation is the only effective treatment for the end-stage fibrotic diseases with inherent limitations. Recent advancements in engineered 3D in vitro human disease mimic models, recapitulating the tissue pathophysiology, have provided unique state-of-the-art platforms for: (i) understanding the biological mechanisms involved in the disease pathogenesis; and (ii) high-throughput and reproducible drug screening. This review focuses on the recent multidisciplinary developments made towards advanced 3D biomimetic fibrotic tissue (liver, kidney, and lung) models that combine highly precision manufacturing techniques with high cellular functionality and biophysical (mechanical) properties.",
keywords = "biofabrication, fibrosis, screening, self-assembly, tissue models",
author = "Marta Sacchi and Ruchi Bansal and Jeroen Rouwkema",
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Bioengineered 3D Models to Recapitulate Tissue Fibrosis. / Sacchi, Marta; Bansal, Ruchi; Rouwkema, Jeroen.

In: Trends in biotechnology, 15.01.2020.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Bioengineered 3D Models to Recapitulate Tissue Fibrosis

AU - Sacchi, Marta

AU - Bansal, Ruchi

AU - Rouwkema, Jeroen

PY - 2020/1/15

Y1 - 2020/1/15

N2 - Fibrosis, characterized by progressive tissue stiffening resulting in organ failure, is a growing health problem affecting millions of people worldwide. Currently, therapeutic options for tissue fibrosis are severely limited and organ transplantation is the only effective treatment for the end-stage fibrotic diseases with inherent limitations. Recent advancements in engineered 3D in vitro human disease mimic models, recapitulating the tissue pathophysiology, have provided unique state-of-the-art platforms for: (i) understanding the biological mechanisms involved in the disease pathogenesis; and (ii) high-throughput and reproducible drug screening. This review focuses on the recent multidisciplinary developments made towards advanced 3D biomimetic fibrotic tissue (liver, kidney, and lung) models that combine highly precision manufacturing techniques with high cellular functionality and biophysical (mechanical) properties.

AB - Fibrosis, characterized by progressive tissue stiffening resulting in organ failure, is a growing health problem affecting millions of people worldwide. Currently, therapeutic options for tissue fibrosis are severely limited and organ transplantation is the only effective treatment for the end-stage fibrotic diseases with inherent limitations. Recent advancements in engineered 3D in vitro human disease mimic models, recapitulating the tissue pathophysiology, have provided unique state-of-the-art platforms for: (i) understanding the biological mechanisms involved in the disease pathogenesis; and (ii) high-throughput and reproducible drug screening. This review focuses on the recent multidisciplinary developments made towards advanced 3D biomimetic fibrotic tissue (liver, kidney, and lung) models that combine highly precision manufacturing techniques with high cellular functionality and biophysical (mechanical) properties.

KW - biofabrication

KW - fibrosis

KW - screening

KW - self-assembly

KW - tissue models

U2 - 10.1016/j.tibtech.2019.12.010

DO - 10.1016/j.tibtech.2019.12.010

M3 - Review article

AN - SCOPUS:85077926334

JO - Trends in biotechnology

JF - Trends in biotechnology

SN - 0167-7799

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