Bioengineering Organs for Blood Detoxification

Cécile Legallais, Dooli Kim, Sylvia M. Mihaila, Milos Mihajlovic, Marina Figliuzzi, Barbara Bonandrini, Simona Salerno, Fjodor A. Yousef Yengej, Maarten B. Rookmaaker, Natalia Sanchez Romero, Pilar Sainz-Arnal, Ulysse Pereira, Mattia Pasqua, Karin G.F. Gerritsen, Marianne C. Verhaar, Andrea Remuzzi, Pedro M. Baptista, Loredana De Bartolo, Rosalinde Masereeuw, Dimitrios Stamatialis (Corresponding Author)

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Abstract

For patients with severe kidney or liver failure the best solution is currently organ transplantation. However, not all patients are eligible for transplantation and due to limited organ availability, most patients are currently treated with therapies using artificial kidney and artificial liver devices. These therapies, despite their relative success in preserving the patients' life, have important limitations since they can only replace part of the natural kidney or liver functions. As blood detoxification (and other functions) in these highly perfused organs is achieved by specialized cells, it seems relevant to review the approaches leading to bioengineered organs fulfilling most of the native organ functions. There, the culture of cells of specific phenotypes on adapted scaffolds that can be perfused takes place. In this review paper, first the functions of kidney and liver organs are briefly described. Then artificial kidney/liver devices, bioartificial kidney devices, and bioartificial liver devices are focused on, as well as biohybrid constructs obtained by decellularization and recellularization of animal organs. For all organs, a thorough overview of the literature is given and the perspectives for their application in the clinic are discussed.

Original languageEnglish
Article number1800430
JournalAdvanced healthcare materials
Volume7
Issue number21
DOIs
Publication statusPublished - 7 Nov 2018

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Bioengineering
Detoxification
Artificial Liver
Liver
Blood
Artificial Kidneys
Equipment and Supplies
Kidney
Animal Structures
Liver Failure
Organ Transplantation
Transplantation (surgical)
Renal Insufficiency
Cell Culture Techniques
Transplantation
Phenotype
Scaffolds
Animals
Therapeutics
Availability

Keywords

  • UT-Hybrid-D
  • blood detoxification
  • kidneys
  • livers
  • bioengineered organs

Cite this

Legallais, C., Kim, D., Mihaila, S. M., Mihajlovic, M., Figliuzzi, M., Bonandrini, B., ... Stamatialis, D. (2018). Bioengineering Organs for Blood Detoxification. Advanced healthcare materials, 7(21), [1800430]. https://doi.org/10.1002/adhm.201800430
Legallais, Cécile ; Kim, Dooli ; Mihaila, Sylvia M. ; Mihajlovic, Milos ; Figliuzzi, Marina ; Bonandrini, Barbara ; Salerno, Simona ; Yousef Yengej, Fjodor A. ; Rookmaaker, Maarten B. ; Sanchez Romero, Natalia ; Sainz-Arnal, Pilar ; Pereira, Ulysse ; Pasqua, Mattia ; Gerritsen, Karin G.F. ; Verhaar, Marianne C. ; Remuzzi, Andrea ; Baptista, Pedro M. ; De Bartolo, Loredana ; Masereeuw, Rosalinde ; Stamatialis, Dimitrios. / Bioengineering Organs for Blood Detoxification. In: Advanced healthcare materials. 2018 ; Vol. 7, No. 21.
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Legallais, C, Kim, D, Mihaila, SM, Mihajlovic, M, Figliuzzi, M, Bonandrini, B, Salerno, S, Yousef Yengej, FA, Rookmaaker, MB, Sanchez Romero, N, Sainz-Arnal, P, Pereira, U, Pasqua, M, Gerritsen, KGF, Verhaar, MC, Remuzzi, A, Baptista, PM, De Bartolo, L, Masereeuw, R & Stamatialis, D 2018, 'Bioengineering Organs for Blood Detoxification' Advanced healthcare materials, vol. 7, no. 21, 1800430. https://doi.org/10.1002/adhm.201800430

Bioengineering Organs for Blood Detoxification. / Legallais, Cécile; Kim, Dooli; Mihaila, Sylvia M.; Mihajlovic, Milos; Figliuzzi, Marina; Bonandrini, Barbara; Salerno, Simona; Yousef Yengej, Fjodor A.; Rookmaaker, Maarten B.; Sanchez Romero, Natalia; Sainz-Arnal, Pilar; Pereira, Ulysse; Pasqua, Mattia; Gerritsen, Karin G.F.; Verhaar, Marianne C.; Remuzzi, Andrea; Baptista, Pedro M.; De Bartolo, Loredana; Masereeuw, Rosalinde; Stamatialis, Dimitrios (Corresponding Author).

In: Advanced healthcare materials, Vol. 7, No. 21, 1800430, 07.11.2018.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Bioengineering Organs for Blood Detoxification

AU - Legallais, Cécile

AU - Kim, Dooli

AU - Mihaila, Sylvia M.

AU - Mihajlovic, Milos

AU - Figliuzzi, Marina

AU - Bonandrini, Barbara

AU - Salerno, Simona

AU - Yousef Yengej, Fjodor A.

AU - Rookmaaker, Maarten B.

AU - Sanchez Romero, Natalia

AU - Sainz-Arnal, Pilar

AU - Pereira, Ulysse

AU - Pasqua, Mattia

AU - Gerritsen, Karin G.F.

AU - Verhaar, Marianne C.

AU - Remuzzi, Andrea

AU - Baptista, Pedro M.

AU - De Bartolo, Loredana

AU - Masereeuw, Rosalinde

AU - Stamatialis, Dimitrios

N1 - Wiley deal

PY - 2018/11/7

Y1 - 2018/11/7

N2 - For patients with severe kidney or liver failure the best solution is currently organ transplantation. However, not all patients are eligible for transplantation and due to limited organ availability, most patients are currently treated with therapies using artificial kidney and artificial liver devices. These therapies, despite their relative success in preserving the patients' life, have important limitations since they can only replace part of the natural kidney or liver functions. As blood detoxification (and other functions) in these highly perfused organs is achieved by specialized cells, it seems relevant to review the approaches leading to bioengineered organs fulfilling most of the native organ functions. There, the culture of cells of specific phenotypes on adapted scaffolds that can be perfused takes place. In this review paper, first the functions of kidney and liver organs are briefly described. Then artificial kidney/liver devices, bioartificial kidney devices, and bioartificial liver devices are focused on, as well as biohybrid constructs obtained by decellularization and recellularization of animal organs. For all organs, a thorough overview of the literature is given and the perspectives for their application in the clinic are discussed.

AB - For patients with severe kidney or liver failure the best solution is currently organ transplantation. However, not all patients are eligible for transplantation and due to limited organ availability, most patients are currently treated with therapies using artificial kidney and artificial liver devices. These therapies, despite their relative success in preserving the patients' life, have important limitations since they can only replace part of the natural kidney or liver functions. As blood detoxification (and other functions) in these highly perfused organs is achieved by specialized cells, it seems relevant to review the approaches leading to bioengineered organs fulfilling most of the native organ functions. There, the culture of cells of specific phenotypes on adapted scaffolds that can be perfused takes place. In this review paper, first the functions of kidney and liver organs are briefly described. Then artificial kidney/liver devices, bioartificial kidney devices, and bioartificial liver devices are focused on, as well as biohybrid constructs obtained by decellularization and recellularization of animal organs. For all organs, a thorough overview of the literature is given and the perspectives for their application in the clinic are discussed.

KW - UT-Hybrid-D

KW - blood detoxification

KW - kidneys

KW - livers

KW - bioengineered organs

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U2 - 10.1002/adhm.201800430

DO - 10.1002/adhm.201800430

M3 - Review article

VL - 7

JO - Advanced healthcare materials

JF - Advanced healthcare materials

SN - 2192-2640

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ER -

Legallais C, Kim D, Mihaila SM, Mihajlovic M, Figliuzzi M, Bonandrini B et al. Bioengineering Organs for Blood Detoxification. Advanced healthcare materials. 2018 Nov 7;7(21). 1800430. https://doi.org/10.1002/adhm.201800430