Biofunctionalized Lipid-Polymer Hybrid Nanocontainers with Controlled Permeability

Alma Dudia; Armagan Kocer; Vinod Subramaniam; Johannes S. Kanger

doi:10.1021/nl073211b

Biofunctionalized Lipid-Polymer Hybrid Nanocontainers with Controlled Permeability

Alma Dudia, Armagan Kocer, Vinod Subramaniam, Johannes S. Kanger

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

12 Downloads (Pure)

Abstract

We have successfully developed, for the first time, a novel polymer–lipid hybrid nanocontainer with controlled permeability functionality. The nanocontainer is made by nanofabricating holes with desired dimensions in an impermeable polymer scaffold by focused ion beam drilling and sealing them with lipid bilayers containing remote-controlled pore-forming channel proteins. This system allows exchange of solutions only after channel activation at will to form temporary pores in the container. Potential applications are foreseen in bionanosensors, nanoreactors, nanomedicine, and triggered delivery.

Original language	English
Pages (from-to)	1105-1110
Number of pages	6
Journal	Nano letters
Volume	8
Issue number	4
DOIs	https://doi.org/10.1021/nl073211b
Publication status	Published - 2008

Keywords

n/a OA procedure

Access to Document

10.1021/nl073211b

Cite this

@article{3698c8c268d84d918fcda4fd5fb52931,

title = "Biofunctionalized Lipid-Polymer Hybrid Nanocontainers with Controlled Permeability",

abstract = "We have successfully developed, for the first time, a novel polymer–lipid hybrid nanocontainer with controlled permeability functionality. The nanocontainer is made by nanofabricating holes with desired dimensions in an impermeable polymer scaffold by focused ion beam drilling and sealing them with lipid bilayers containing remote-controlled pore-forming channel proteins. This system allows exchange of solutions only after channel activation at will to form temporary pores in the container. Potential applications are foreseen in bionanosensors, nanoreactors, nanomedicine, and triggered delivery.",

keywords = "n/a OA procedure",

author = "Alma Dudia and Armagan Kocer and Vinod Subramaniam and Kanger, {Johannes S.}",

year = "2008",

doi = "10.1021/nl073211b",

language = "English",

volume = "8",

pages = "1105--1110",

journal = "Nano letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - Biofunctionalized Lipid-Polymer Hybrid Nanocontainers with Controlled Permeability

AU - Dudia, Alma

AU - Kocer, Armagan

AU - Subramaniam, Vinod

AU - Kanger, Johannes S.

PY - 2008

Y1 - 2008

N2 - We have successfully developed, for the first time, a novel polymer–lipid hybrid nanocontainer with controlled permeability functionality. The nanocontainer is made by nanofabricating holes with desired dimensions in an impermeable polymer scaffold by focused ion beam drilling and sealing them with lipid bilayers containing remote-controlled pore-forming channel proteins. This system allows exchange of solutions only after channel activation at will to form temporary pores in the container. Potential applications are foreseen in bionanosensors, nanoreactors, nanomedicine, and triggered delivery.

AB - We have successfully developed, for the first time, a novel polymer–lipid hybrid nanocontainer with controlled permeability functionality. The nanocontainer is made by nanofabricating holes with desired dimensions in an impermeable polymer scaffold by focused ion beam drilling and sealing them with lipid bilayers containing remote-controlled pore-forming channel proteins. This system allows exchange of solutions only after channel activation at will to form temporary pores in the container. Potential applications are foreseen in bionanosensors, nanoreactors, nanomedicine, and triggered delivery.

KW - n/a OA procedure

U2 - 10.1021/nl073211b

DO - 10.1021/nl073211b

M3 - Article

SN - 1530-6984

VL - 8

SP - 1105

EP - 1110

JO - Nano letters

JF - Nano letters

IS - 4

ER -

Biofunctionalized Lipid-Polymer Hybrid Nanocontainers with Controlled Permeability

Abstract

Keywords

Access to Document

Fingerprint

Cite this