Biofunctionalized Lipid - Polymer Hybrid Nanocontainers with Controlled Permeability

A. Dudia, Armagan Kocer, Vinod Subramaniam, Johannes S. Kanger

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

We have successfully developed, for the first time, a novel polymer–lipid hybrid nanocontainer with controlled permeability functionality. The nanocontainer is made by nanofabricating holes with desired dimensions in an impermeable polymer scaffold by focused ion beam drilling and sealing them with lipid bilayers containing remote-controlled pore-forming channel proteins. This system allows exchange of solutions only after channel activation at will to form temporary pores in the container. Potential applications are foreseen in bionanosensors, nanoreactors, nanomedicine, and triggered delivery.
Original languageUndefined
Pages (from-to)1105-1110
Number of pages6
JournalNano letters
Volume8
Issue number4
DOIs
Publication statusPublished - 2008

Keywords

  • IR-59462
  • METIS-247369

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