Biological performance of uncoated and octacalcium phosphate-coated Ti6A14V

Pamela Habibovic, L. Li Jiaping, Chantal M. van der Valk, Gert Meijer, Pierre Layrolle, Clemens van Blitterswijk, K. de Groot

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The in vivo behavior of a porous Ti6Al4V material that was produced by a positive replica technique, with and without an octacalcium phosphate (OCP) coating, has been studied both in the back muscle and femur of goats. Macro- and microporous biphasic calcium phosphate (BCP) ceramic, known to be both osteoconductive and able to induce ectopic bone formation, was used for comparison purpose. The three groups of materials (Ti6Al4V, OCP Ti6Al4V and BCP) were implanted transcortically and intramuscularly for 6 and 12 weeks in 10 adult Dutch milk goats in order to study their osteointegration and osteoinductive potential. In femoral defects, both OCP Ti6Al4V and BCP were performing better than the uncoated Ti6Al4V, at both time points. BCP showed a higher bone amount than OCP Ti6Al4V after 6 weeks of implantation, while after 12 weeks, this difference was no longer significant. Ectopic bone formation was found in both OCP Ti6Al4V and BCP implants after 6 and 12 weeks. The quantity of ectopically formed bone was limited as was the amount of animals in which the bone was observed. Ectopic bone formation was not found in uncoated titanium alloy implants, suggesting that the presence of calcium phosphate (CaP) is important for bone induction. This study showed that CaPs in the form of coating on metal implants or in the form of bulk ceramic have a significantly positive effect on the bone healing process.
Original languageUndefined
Pages (from-to)23-36
Issue number1
Publication statusPublished - 2005


  • Biphasic calcium phosphate (BCP)
  • Biomimetic coatings
  • Octacalcium phosphate (OCP)
  • Porous Ti6Al4V
  • Osteoinduction
  • Osteointegration
  • METIS-223534
  • IR-80976

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