Biomaterials in search of a meniscus substitute

J.J. Rongen, T.G. van Tienen, Bas van Bochove, Dirk W. Grijpma, P. Buma

Research output: Contribution to journalArticleAcademicpeer-review

59 Citations (Scopus)

Abstract

The menisci fulfill key biomechanical functions in the tibiofemoral (knee) joint. Unfortunately meniscal injuries are quite common and most often treated by (partial) meniscectomy. However, some patients experience enduring symptoms, and, more importantly, it leads to an increased risk for symptomatic osteoarthritis. Over the past decades, researchers have put effort in developing a meniscal substitute able to prevent osteoarthritis and treat enduring clinical symptoms. Grossly, two categories of substitutes are observed: First, a resorbable scaffold mimicking biomechanical function which slowly degrades while tissue regeneration and organization is promoted. Second, a non resorbable, permanent implant which mimics the biomechanical function of the native meniscus. Numerous biomaterials with different (material) properties have been used in order to provide such a substitute. Nevertheless, a clinically applicable cartilage protecting material is not yet emerged. In the current review we provide an overview, and discuss, these different materials and extract recommendations regarding material properties for future developmental research.
Original languageEnglish
Pages (from-to)3527-3540
JournalBiomaterials
Volume35
Issue number11
DOIs
Publication statusPublished - 2014

Keywords

  • METIS-308085
  • IR-95038

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