Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

J. Ribas, Y.S. Zhang, P.R. Pitrez, Jeroen Christianus Hermanus Leijten, M. Miscuglio, Jeroen Rouwkema, M.R. Dokmeci, X. Nissan, L. Ferreira, A. Khademhosseini

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)


A progeria-on-a-chip model is engineered to recapitulate the biomechanical dynamics of vascular disease and aging. The model shows an exacerbated injury response to strain and is rescued by pharmacological treatments. The progeria-on-a-chip is expected to drive the discovery of new drugs and to elucidate the role of strain in vascular aging and disease.
Original languageEnglish
Article number1603737
Number of pages13
Issue number15
Publication statusPublished - 17 Feb 2017


  • IR-103556
  • METIS-321600


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