Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

J. Ribas; Y.S. Zhang; P.R. Pitrez; Jeroen Christianus Hermanus Leijten; M. Miscuglio; Jeroen Rouwkema; M.R. Dokmeci; X. Nissan; L. Ferreira; A. Khademhosseini

doi:10.1002/smll.201603737

Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

J. Ribas, Y.S. Zhang, P.R. Pitrez, Jeroen Christianus Hermanus Leijten, M. Miscuglio, Jeroen Rouwkema, M.R. Dokmeci, X. Nissan, L. Ferreira, A. Khademhosseini

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Abstract

A progeria-on-a-chip model is engineered to recapitulate the biomechanical dynamics of vascular disease and aging. The model shows an exacerbated injury response to strain and is rescued by pharmacological treatments. The progeria-on-a-chip is expected to drive the discovery of new drugs and to elucidate the role of strain in vascular aging and disease.

Original language	English
Article number	1603737
Number of pages	13
Journal	Small
Volume	13
Issue number	15
DOIs	https://doi.org/10.1002/smll.201603737
Publication status	Published - 17 Feb 2017

Keywords

IR-103556
METIS-321600
22/4 OA procedure

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/smll.201603737

Ribas2017biomechanicalFinal published version, 4.56 MBLicence: Taverne

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title = "Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model",

abstract = "A progeria-on-a-chip model is engineered to recapitulate the biomechanical dynamics of vascular disease and aging. The model shows an exacerbated injury response to strain and is rescued by pharmacological treatments. The progeria-on-a-chip is expected to drive the discovery of new drugs and to elucidate the role of strain in vascular aging and disease.",

keywords = "IR-103556, METIS-321600, 22/4 OA procedure",

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AU - Ribas, J.

AU - Zhang, Y.S.

AU - Pitrez, P.R.

AU - Leijten, Jeroen Christianus Hermanus

AU - Miscuglio, M.

AU - Rouwkema, Jeroen

AU - Dokmeci, M.R.

AU - Nissan, X.

AU - Ferreira, L.

AU - Khademhosseini, A.

PY - 2017/2/17

Y1 - 2017/2/17

N2 - A progeria-on-a-chip model is engineered to recapitulate the biomechanical dynamics of vascular disease and aging. The model shows an exacerbated injury response to strain and is rescued by pharmacological treatments. The progeria-on-a-chip is expected to drive the discovery of new drugs and to elucidate the role of strain in vascular aging and disease.

AB - A progeria-on-a-chip model is engineered to recapitulate the biomechanical dynamics of vascular disease and aging. The model shows an exacerbated injury response to strain and is rescued by pharmacological treatments. The progeria-on-a-chip is expected to drive the discovery of new drugs and to elucidate the role of strain in vascular aging and disease.

KW - IR-103556

KW - METIS-321600

KW - 22/4 OA procedure

U2 - 10.1002/smll.201603737

DO - 10.1002/smll.201603737

M3 - Article

SN - 1613-6810

VL - 13

JO - Small

JF - Small

IS - 15

M1 - 1603737

ER -

Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

Abstract

Keywords

UN SDGs

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