Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

J. Ribas, Y.S. Zhang, P.R. Pitrez, Jeroen Christianus Hermanus Leijten, M. Miscuglio, Jeroen Rouwkema, M.R. Dokmeci, X. Nissan, L. Ferreira, A. Khademhosseini

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

A progeria-on-a-chip model is engineered to recapitulate the biomechanical dynamics of vascular disease and aging. The model shows an exacerbated injury response to strain and is rescued by pharmacological treatments. The progeria-on-a-chip is expected to drive the discovery of new drugs and to elucidate the role of strain in vascular aging and disease.
Original languageEnglish
Article number1603737
Number of pages13
JournalSmall
Volume13
Issue number15
DOIs
Publication statusPublished - 17 Feb 2017

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Progeria
Vascular Diseases
Aging of materials
Inflammation
Drug Discovery
Pharmacology
Wounds and Injuries
Pharmaceutical Preparations

Keywords

  • IR-103556
  • METIS-321600

Cite this

Ribas, J., Zhang, Y. S., Pitrez, P. R., Leijten, J. C. H., Miscuglio, M., Rouwkema, J., ... Khademhosseini, A. (2017). Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model. Small, 13(15), [1603737]. https://doi.org/10.1002/smll.201603737
Ribas, J. ; Zhang, Y.S. ; Pitrez, P.R. ; Leijten, Jeroen Christianus Hermanus ; Miscuglio, M. ; Rouwkema, Jeroen ; Dokmeci, M.R. ; Nissan, X. ; Ferreira, L. ; Khademhosseini, A. / Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model. In: Small. 2017 ; Vol. 13, No. 15.
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Ribas, J, Zhang, YS, Pitrez, PR, Leijten, JCH, Miscuglio, M, Rouwkema, J, Dokmeci, MR, Nissan, X, Ferreira, L & Khademhosseini, A 2017, 'Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model' Small, vol. 13, no. 15, 1603737. https://doi.org/10.1002/smll.201603737

Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model. / Ribas, J.; Zhang, Y.S.; Pitrez, P.R.; Leijten, Jeroen Christianus Hermanus; Miscuglio, M.; Rouwkema, Jeroen; Dokmeci, M.R.; Nissan, X.; Ferreira, L.; Khademhosseini, A.

In: Small, Vol. 13, No. 15, 1603737, 17.02.2017.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

AU - Ribas, J.

AU - Zhang, Y.S.

AU - Pitrez, P.R.

AU - Leijten, Jeroen Christianus Hermanus

AU - Miscuglio, M.

AU - Rouwkema, Jeroen

AU - Dokmeci, M.R.

AU - Nissan, X.

AU - Ferreira, L.

AU - Khademhosseini, A.

PY - 2017/2/17

Y1 - 2017/2/17

N2 - A progeria-on-a-chip model is engineered to recapitulate the biomechanical dynamics of vascular disease and aging. The model shows an exacerbated injury response to strain and is rescued by pharmacological treatments. The progeria-on-a-chip is expected to drive the discovery of new drugs and to elucidate the role of strain in vascular aging and disease.

AB - A progeria-on-a-chip model is engineered to recapitulate the biomechanical dynamics of vascular disease and aging. The model shows an exacerbated injury response to strain and is rescued by pharmacological treatments. The progeria-on-a-chip is expected to drive the discovery of new drugs and to elucidate the role of strain in vascular aging and disease.

KW - IR-103556

KW - METIS-321600

U2 - 10.1002/smll.201603737

DO - 10.1002/smll.201603737

M3 - Article

VL - 13

JO - Small

JF - Small

SN - 1613-6810

IS - 15

M1 - 1603737

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