TY - JOUR
T1 - Biomedical applications of polysaccharide nanoparticles for chronic inflammatory disorders
T2 - Focus on rheumatoid arthritis, diabetes and organ fibrosis
AU - Allawadhi, Prince
AU - Singh, V.
AU - Govindaraj, Kannan
AU - Khurana, Isha
AU - Sarode, Lopmudra P.
AU - Navik, Umashanker
AU - Banothu, Anil Kumar
AU - Weiskirchen, Ralf
AU - Bharani, Kala Kumar
AU - Khurana, Amit
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Polysaccharides are biopolymers distinguished by their complex secondary structures executing various roles in microorganisms, plants, and animals. They are made up of long monomers of similar type or as a combination of other monomeric chains. Polysaccharides are considered superior as compared to other polymers due to their diversity in charge and size, biodegradability, abundance, bio-compatibility, and less toxicity. These natural polymers are widely used in designing of nanoparticles (NPs) which possess wide applications in therapeutics, diagnostics, delivery and protection of bioactive compounds or drugs. The side chain reactive groups of polysaccharides are advantageous for functionalization with nanoparticle-based conjugates or therapeutic agents such as small molecules, proteins, peptides and nucleic acids. Polysaccharide NPs show excellent pharmacokinetic and drug delivery properties, facilitate improved oral absorption, control the release of drugs, increases in vivo retention capability, targeted delivery, and exert synergistic effects. This review updates the usage of polysaccharides based NPs particularly cellulose, chitosan, hyaluronic acid, alginate, dextran, starch, cyclodextrins, pullulan, and their combinations with promising applications in diabetes, organ fibrosis and arthritis.
AB - Polysaccharides are biopolymers distinguished by their complex secondary structures executing various roles in microorganisms, plants, and animals. They are made up of long monomers of similar type or as a combination of other monomeric chains. Polysaccharides are considered superior as compared to other polymers due to their diversity in charge and size, biodegradability, abundance, bio-compatibility, and less toxicity. These natural polymers are widely used in designing of nanoparticles (NPs) which possess wide applications in therapeutics, diagnostics, delivery and protection of bioactive compounds or drugs. The side chain reactive groups of polysaccharides are advantageous for functionalization with nanoparticle-based conjugates or therapeutic agents such as small molecules, proteins, peptides and nucleic acids. Polysaccharide NPs show excellent pharmacokinetic and drug delivery properties, facilitate improved oral absorption, control the release of drugs, increases in vivo retention capability, targeted delivery, and exert synergistic effects. This review updates the usage of polysaccharides based NPs particularly cellulose, chitosan, hyaluronic acid, alginate, dextran, starch, cyclodextrins, pullulan, and their combinations with promising applications in diabetes, organ fibrosis and arthritis.
KW - 2022 OA procedure
KW - Drug delivery
KW - Inflammation
KW - Nanoparticles
KW - Polysaccharides
KW - Arthritis
UR - http://www.scopus.com/inward/record.url?scp=85121138960&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2021.118923
DO - 10.1016/j.carbpol.2021.118923
M3 - Review article
SN - 0144-8617
VL - 281
JO - Carbohydrate polymers
JF - Carbohydrate polymers
M1 - 118923
ER -