Biomimetic Architectures for Peripheral Nerve Repair: A Review of Biofabrication Strategies

Paul A. Wieringa, Ana Rita Gonçalves de Pinho, Silvestro Micera, Richard J.A. van Wezel, Lorenzo Moroni* (Corresponding Author)

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    15 Citations (Scopus)

    Abstract

    Biofabrication techniques have endeavored to improve the regeneration of the peripheral nervous system (PNS), but nothing has surpassed the performance of current clinical practices. However, these current approaches have intrinsic limitations that compromise patient care. The “gold standard” autograft provides the best outcomes but requires suitable donor material, while implantable hollow nerve guide conduits (NGCs) can only repair small nerve defects. This review places emphasis on approaches that create structural cues within a hollow NGC lumen in order to match or exceed the regenerative performance of the autograft. An overview of the PNS and nerve regeneration is provided. This is followed by an assessment of reported devices, divided into three major categories: isotropic hydrogel fillers, acting as unstructured interluminal support for regenerating nerves; fibrous interluminal fillers, presenting neurites with topographical guidance within the lumen; and patterned interluminal scaffolds, providing 3D support for nerve growth via structures that mimic native PNS tissue. Also presented is a critical framework to evaluate the impact of reported outcomes. While a universal and versatile nerve repair strategy remains elusive, outlined here is a roadmap of past, present, and emerging fabrication techniques to inform and motivate new developments in the field of peripheral nerve regeneration.

    Original languageEnglish
    Article number1701164
    JournalAdvanced healthcare materials
    Volume7
    Issue number8
    Early online date19 Jan 2018
    DOIs
    Publication statusPublished - 25 Apr 2018

    Fingerprint

    Biomimetics
    Peripheral Nervous System
    Neurology
    Peripheral Nerves
    Nerve Regeneration
    Repair
    Autografts
    Fillers
    Nerve Tissue
    Hydrogel
    Neurites
    Hydrogels
    Scaffolds
    Cues
    Regeneration
    Patient Care
    Tissue
    Fabrication
    Equipment and Supplies
    Defects

    Keywords

    • UT-Hybrid-D
    • biomimicry
    • nerve guides
    • peripheral nerve regeneration
    • structural cues
    • biofabrication

    Cite this

    Wieringa, Paul A. ; Gonçalves de Pinho, Ana Rita ; Micera, Silvestro ; van Wezel, Richard J.A. ; Moroni, Lorenzo. / Biomimetic Architectures for Peripheral Nerve Repair : A Review of Biofabrication Strategies. In: Advanced healthcare materials. 2018 ; Vol. 7, No. 8.
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    Biomimetic Architectures for Peripheral Nerve Repair : A Review of Biofabrication Strategies. / Wieringa, Paul A.; Gonçalves de Pinho, Ana Rita; Micera, Silvestro; van Wezel, Richard J.A.; Moroni, Lorenzo (Corresponding Author).

    In: Advanced healthcare materials, Vol. 7, No. 8, 1701164, 25.04.2018.

    Research output: Contribution to journalArticleAcademicpeer-review

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